Insight into HIV of IFN-Induced Myxovirus Resistance 2 (MX2) Expressed by Traditional Chinese Medicine

Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Ch...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-14
Main Authors: Hung, Tzu-Chieh, Lee, Wen-Yuan, Chen, Kuen-Bao, Chan, Yueh-Chiu, Chen, Calvin Yu-Chian
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - genetics
Acquired Immunodeficiency Syndrome - virology
AIDS
Asparagine - analogs & derivatives
Asparagine - chemistry
Asparagine - therapeutic use
Chinese medicine
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - therapeutic use
Gene Expression Regulation - drug effects
HIV
HIV - drug effects
HIV - genetics
HIV infection
Hospitals
Human immunodeficiency virus
Human immunodeficiency virus 2
Humans
Interferon
Ligands
Medical research
Medicine, Chinese
Medicine, Chinese Traditional
Molecular Docking Simulation
Molecular Dynamics Simulation
Myxovirus Resistance Proteins - antagonists & inhibitors
Myxovirus Resistance Proteins - biosynthesis
Pyrrolizidine Alkaloids - chemistry
Pyrrolizidine Alkaloids - therapeutic use
Tryptophan - analogs & derivatives
Tryptophan - chemistry
Tryptophan - therapeutic use
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Summary:Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Chinese Medicine (TCM) database by simulating molecular docking and molecular dynamics could select candidate compounds, which may express MX2 against HIV. Saussureamine C, Crotalaburnine, and Precatorine are selected based on the highest docking score and other TCM compounds. The data from molecular dynamics are helpful in the analysis and detection of protein-ligand interactions. According to the docking poses, hydrophobic interactions, and hydrogen bond with structure variations, this research could assess the interaction between protein and ligand interaction. In addition to the detection of TCM compound efficacy, we suggest that Saussureamine C is better than the others in protein-ligand interaction and the structural variation to express MX2.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/871576