Pine Oil Effects on Chemical and Thermal Injury in Mice and Cultured Mouse Dorsal Root Ganglion Neurons

A commercial resin‐based pine oil (PO) derived from Pinus palustris and Pinus elliottii was the major focus of this investigation. Extracts of pine resins, needles, and bark are folk medicines commonly used to treat skin ailments, including burns. The American Burn Association estimates that 500,000...

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Bibliographic Details
Published in:Phytotherapy research 2014-02, Vol.28 (2), p.252-260
Main Authors: Clark, S. P., Bollag, W. B., Westlund, K. N., Ma, F., Falls, G., Xie, D., Johnson, M., Isales, C. M., Bhattacharyya, M. H.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate
Animals
Burns - drug therapy
Capsaicin
Cells, Cultured
Dermatitis - drug therapy
Disease Models, Animal
dorsal root ganglion (DRG) neuronal cells
edema
Ganglia, Spinal - drug effects
Hyperalgesia - drug therapy
Male
Mice
Mice, Inbred C57BL
Mice, Inbred ICR
mouse
Neurons - drug effects
Neurons - metabolism
pain
Pain - drug therapy
pine oil treatment
Pinus - chemistry
Pinus elliottii
Pinus palustris
Plant Oils - pharmacology
Resins, Plant - pharmacology
scald burn
Skin - pathology
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Summary:A commercial resin‐based pine oil (PO) derived from Pinus palustris and Pinus elliottii was the major focus of this investigation. Extracts of pine resins, needles, and bark are folk medicines commonly used to treat skin ailments, including burns. The American Burn Association estimates that 500,000 people with burn injuries receive medical treatment each year; one‐half of US burn victims are children, most with scald burns. This systematic study was initiated as follow‐up to personal anecdotal evidence acquired over more than 10 years by MH Bhattacharyya regarding PO's efficacy for treating burns. The results demonstrate that PO counteracted dermal inflammation in both a mouse ear model of contact irritant‐induced dermal inflammation and a second degree scald burn to the mouse paw. Furthermore, PO significantly counteracted the tactile allodynia and soft tissue injury caused by the scald burn. In mouse dorsal root ganglion neuronal cultures, PO added to the medium blocked adenosine triphosphate‐activated, but not capsaicin‐activated, pain pathways, demonstrating specificity. These results together support the hypothesis that a pine‐oil‐based treatment can be developed to provide effective in‐home care for second degree burns. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.4991