Definition and characterization of an extended social-affective default network

Recent evidence suggests considerable overlap between the default mode network (DMN) and regions involved in social, affective and introspective processes. We considered these overlapping regions as the social-affective part of the DMN. In this study, we established a robust mapping of the underlyin...

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Bibliographic Details
Published in:Brain Structure and Function 2015-03, Vol.220 (2), p.1031-1049
Main Authors: Amft, Maren, Bzdok, Danilo, Laird, Angela R., Fox, Peter T., Schilbach, Leonhard, Eickhoff, Simon B.
Format: Article
Language:English
Subjects:
Adult
Affect
Biomedical and Life Sciences
Biomedicine
Brain - cytology
Brain - physiology
Brain Mapping - methods
Brain research
Cell Biology
Cluster Analysis
Cognition
Databases, Factual
Female
Humans
Magnetic Resonance Imaging
Male
Memory
Middle Aged
Models, Neurological
Motivation
Nerve Net - cytology
Nerve Net - physiology
Neurology
Neurosciences
Original Article
Retrospective Studies
Self Concept
Social Behavior
Theory of Mind
Young Adult
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Summary:Recent evidence suggests considerable overlap between the default mode network (DMN) and regions involved in social, affective and introspective processes. We considered these overlapping regions as the social-affective part of the DMN. In this study, we established a robust mapping of the underlying brain network formed by these regions and those strongly connected to them (the extended social-affective default network). We first seeded meta-analytic connectivity modeling and resting-state analyses in the meta-analytically defined DMN regions that showed statistical overlap with regions associated with social and affective processing. Consensus connectivity of each seed was subsequently delineated by a conjunction across both connectivity analyses. We then functionally characterized the ensuing regions and performed several cluster analyses. Among the identified regions, the amygdala/hippocampus formed a cluster associated with emotional processes and memory functions. The ventral striatum, anterior cingulum, subgenual cingulum and ventromedial prefrontal cortex formed a heterogeneous subgroup associated with motivation, reward and cognitive modulation of affect. Posterior cingulum/precuneus and dorsomedial prefrontal cortex were associated with mentalizing, self-reference and autobiographic information. The cluster formed by the temporo-parietal junction and anterior middle temporal sulcus/gyrus was associated with language and social cognition. Taken together, the current work highlights a robustly interconnected network that may be central to introspective, socio-affective, that is, self- and other-related mental processes.
ISSN:1863-2653
1863-2661
0340-2061
DOI:10.1007/s00429-013-0698-0