Carcinoid of the ampulla of Vater： Morphologic features and clinical implications

Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice. The published data indicate that these tumors, in contrast to their midgut counterparts, metastasize in approximately half of cases irrespective of primary tumor size. Therefore, radical excision in the fo...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2006-11, Vol.12 (43), p.7058-7060
Main Authors: Poultsides, George A, Frederick, Wayne A I
Format: Article
Language:English
Subjects:
Aged
Ampulla of Vater - pathology
Carcinoid Tumor - diagnosis
Carcinoid Tumor - pathology
Case Report
Common Bile Duct Neoplasms - diagnosis
Common Bile Duct Neoplasms - pathology
Common Bile Duct Neoplasms - therapy
Diagnosis, Differential
Humans
Jaundice - diagnosis
Jaundice - pathology
Male
形态学
手术治疗
组织病理学
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Summary:Carcinoids involving the ampulla of Vater are rare lesions that may produce painless jaundice. The published data indicate that these tumors, in contrast to their midgut counterparts, metastasize in approximately half of cases irrespective of primary tumor size. Therefore, radical excision in the form of pancreaticoduodenectomy is recommended regardless of tumor size. As with other gastrointestinal carcinoid tumors, biological treatment with octreotide analogues can be applied to symptomatic patients. Tumor-targeted radioactive therapy is a newly emerging treatment option. We here report case of a carcinoid tumor of the ampulla of Vater presenting as painless jaundice in a 65-year old man and review the relevant literature, giving special attention to the morphologic features, clinical characteristics, and treatment modalities associated with this disease process.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v12.i43.7058