Adverse hepatic reactions associated with calcium carbimide and disulfiram therapy： Is there still a role for these drugs

Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well ch...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2006-08, Vol.12 (31), p.5078-5080
Main Authors: Verge, Carmen, Lucena, M Isabel, López-Torres, Enrique, Puche-Garcia, M José, Fraga, Enrique, Romero-Gomez, Manuel, Andrade, Raúl J
Format: Article
Language:English
Subjects:
Adult
Alcohol Deterrents - adverse effects
Case Report
Chemical and Drug Induced Liver Injury
Cyanamide - adverse effects
Disulfiram - adverse effects
Drug Interactions
Female
Humans
Liver - drug effects
Liver - pathology
Male
Middle Aged
异氰酸脂
戒酒硫
肝中毒
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Summary:Disulfiram and calcium carbimide are two alcohol deterrants widely used in alcoholism treatment, however, there exist great concerns over their safety. Reports on hepatotoxicity, mainly related to disulfiram therapy, have been published. The hepatotoxic potential of calcium carbimide is less well characterized. Here, we describe four cases of liver damage related to this therapeutic group that were submitted to a Registry of hepatotoxicity and point out the limitations that we face when prescribing these compounds. A reassessment of the role of these compounds in the management of alcohol dependence is clearly needed.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v12.i31.5078