Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease

• Published in: World journal of gastroenterology : WJG 2006-06, Vol.12 (22), p.3602-3608
• Main Authors: Vaiphei, Kim, Kumari, Neeraj, Sinha, Saroj-Kant, Dutta, Usha, Nagi, Birinder, Joshi, Kusum, Singh, Kartar
• Format: Article
• Language: English
• Subjects: Adult; Anti-Bacterial Agents - therapeutic use; bcl6; Case-Control Studies; Disease Progression; DNA-Binding Proteins - analysis; DNA-Binding Proteins - genetics; DNA-Binding Proteins - immunology; Doxycycline - therapeutic use; Endoscopy, Gastrointestinal; Female; Gene Expression Regulation; Helicobacter pylori; Humans; Immunoglobulin alpha-Chains - blood; Immunoglobulin alpha-Chains - genetics; Immunoglobulin kappa-Chains - analysis; Immunoglobulin kappa-Chains - genetics; Immunoglobulin lambda-Chains - analysis; Immunoglobulin lambda-Chains - genetics; Immunohistochemistry; Immunoproliferative Small Intestinal Disease - diagnosis; Immunoproliferative Small Intestinal Disease - drug therapy; Immunoproliferative Small Intestinal Disease - genetics; Immunoproliferative Small Intestinal Disease - immunology; Intestinal Mucosa - chemistry; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; Intestine, Small - chemistry; Intestine, Small - microbiology; Intestine, Small - pathology; Male; Membrane Glycoproteins - analysis; Membrane Glycoproteins - genetics; Membrane Glycoproteins - immunology; Middle Aged; p53; Prognosis; Proteoglycans - analysis; Proteoglycans - genetics; Proteoglycans - immunology; Proto-Oncogene Proteins c-bcl-6; Rapid Communication; Syndecan-1; Syndecans; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - immunology; 小肠疾病; 病理机制
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i22.3602

AIM： To evaluate roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease （IPSID） and to study profiles of kappa （κ） and lambda （λ） light chains and IgA heavy chain. METHODS： The study consisted of 11 cases of IPSID and similar number of controls which included 11 of normal intestinal mucosa and 11 of high grade B cell lymphoma of ileum. The parameters analyzed included clinical profiles, biochemical and other laboratory investigations, radiologic and histological findings including immunohistochemistry. RESULTS： All IPSID cases had demonstrable serum IgA heavy chain and heavy mucosal plasma cell infiltration. According to Galian＇s histological staging, there were 4 patients with stage A and 7 with stage B. κ and ;λ light chains were over-expressed in 7 patients; 1 stage A patient had H pylori-positive active gastritis and eradication of H pylori led to disease remission. Stage A biopsies had higher expression for syndecan-1, while stage B had higher expression for bcl6 and p53. Syndecan-1,κ and λ light chains and IgA heavy chain showed inverse relationship with bcl6 and p53. All patients were treated with doxycycline. CHOP regime was added in 5 patients who developed frank lymphoma. Three died of the disease due to extensive organ infiltration. CONCLUSION： Certain immunomarkers like syndecan-1,κ and λ light chains and IgA heavy chain could be of much help in identifying early stage IPSID. Stage B IPSID showed higher expression for bcl6 and p53 than stage A IPSID. bcl6 and p53 expressions correlated with a more advanced disease stage and aggressive tumour behavior.