Host susceptibility to persistent hepatitis B virus infection

Genetic epidemiology researches such as twin studies, family-clustering of hepatitis B virus （HBV） infection studies and ethnic difference studies have provided the evidence that host genetic factors play an important role in determining the outcome of HBV infection. The opening questions include wh...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2006-08, Vol.12 (30), p.4788-4793
Main Authors: He, Ying-Li, Zhao, Ying-Ren, Zhang, Shu-Lin, Lin, Shu-Mei
Format: Article
Language:English
Subjects:
Genetic Linkage
Genetic Predisposition to Disease
Hepatitis B - epidemiology
Hepatitis B - ethnology
Hepatitis B - genetics
Hepatitis B - physiopathology
Hepatitis B virus - metabolism
Hepatitis B virus - pathogenicity
Humans
Polymorphism, Genetic
Review
Twin Studies as Topic
乙型病毒肝炎
病毒感染
磁化率
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Summary:Genetic epidemiology researches such as twin studies, family-clustering of hepatitis B virus （HBV） infection studies and ethnic difference studies have provided the evidence that host genetic factors play an important role in determining the outcome of HBV infection. The opening questions include which human genes are important in infection and how to find them. Though a number of studies have sought genetic associations between HBV infection/persistence and gene polymorphisms, the candidate gene-based approach is clearly inadequate to fully explain the genetic basis of the disease. With the advent of new genetic markers and automated genotyping, genetic mapping can be conducted extremely rapid. This approach has been successful in some infectious diseases. Linkage analysis can find host genes susceptible to HBV and is of great clinical importance.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v12.i30.4788