A pilot randomized control study to evaluate endoscopic resection using a ligation device for rectal carcinoid tumors

• Published in: World journal of gastroenterology : WJG 2006-07, Vol.12 (25), p.4026-4028
• Main Authors: Sakata, Hiroyuki, Iwakiri, Ryuichi, Ootani, Akifumi, Tsunada, Seiji, Ogata, Shinichi, Ootani, Hibiki, Shimoda, Ryo, Yamaguchi, Kanako, Sakata, Yasuhisa, Amemori, Sadahiro, Mannen, Kotaro, Mizuguchi, Masanobu, Fujimoto, Kazuma
• Format: Article
• Language: English
• Subjects: Adult; Aged; Carcinoid Tumor - surgery; Female; Humans; Ligation - instrumentation; Male; Middle Aged; Pilot Projects; Proctoscopy - methods; Rapid Communication; Rectal Neoplasms - surgery; Rectum - surgery; Treatment Outcome; 内窥镜检查; 病理机制; 直肠癌
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i25.4026

AIM： Rectal carcinoid tumors smaller than 10 mm can be resected with local excision using endoscopy. In order to remove rectal carcinoid tumors completely, we evaluated endoscopic mucosal resection with a ligation device in this pilot control randomized study. METHODS： Fifteen patients were diagnosed with rectal carcinoid tumor （less than 10 mm） in our hospital from 1993 to 2002. There were 9 males and 6 females, with a mean age 61.5 years （range, 34-77 years）. The patientshad no complaints of carcinoid syndrome symptoms. Fifteen patients were randomly divided into 2 groups： 7 carcinoid tumors were treated by conventional endoscopic resection, and 8 carcinoid tumors were treated by endoscopic resection using a ligation device. RESULTS： All rectal carcinoid tumors were located at the middle to distal rectum. The size of the tumors varied from 3 mm to 10 mm and background characteristics of the patients were not different in the two groups. The rate of complete removal of carcinoid tumors using a ligation device （100%, 8/8） was significantly higher than that of conventional endoscopic resection （57.1%, 4/7）. The three patients had tumor involvement of deep margin, for which additional treatment was performed. No complications occurred during or after endoscopic resection using a ligation device. All patients in the both groups were alive during the 3-year observation period. CONCLUSION： Endoscopic resection using a ligation device is a useful and safe method for resection of small rectal carcinoid tumors.