Treatment of hepatoma with liposome-encapsulated adriamycin administered into hepatic artery of rats

AIM： To observe the therapeutic effects of liposomeencapsulated adriamycin （LADM） on hepatoma in comparison with adriamycin solution （FADM） and adriarnycin plus blank liposome （ADM ＋ BL） administered into the hepatic artery of rats. METHODS： LADM was prepared by pH gradient-driven method. Normal sal...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2006-08, Vol.12 (29), p.4741-4744
Main Authors: Sun, Dong-Sheng, Chen, Jiang-Hao, Ling, Rui, Yao, Qing, Wang, Ling, Ma, Zhong, Li, Yu
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - therapeutic use
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - pathology
Cell Proliferation - drug effects
Doxorubicin - administration & dosage
Doxorubicin - therapeutic use
Hepatic Artery
Injections, Intra-Arterial
Liposomes
Liver Neoplasms, Experimental - drug therapy
Liver Neoplasms, Experimental - pathology
Male
Necrosis - pathology
Rapid Communication
Rats
Rats, Wistar
抗肿瘤药
肝细胞癌
脂质体
阿霉素
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Summary:AIM： To observe the therapeutic effects of liposomeencapsulated adriamycin （LADM） on hepatoma in comparison with adriamycin solution （FADM） and adriarnycin plus blank liposome （ADM ＋ BL） administered into the hepatic artery of rats. METHODS： LADM was prepared by pH gradient-driven method. Normal saline, FADM （2 mg/kg）, ADM＋BL （2 mg/kg）, and LADM （2 mg/kg） were injected via the hepatic artery in rats bearing liver W256 carcinosarcoma, which were divided into four groups randomly. The therapeutic effects were evaluated in terms of survival time, tumor enlargement ratio, and tumor necrosis degree. The difference was determined with ANOVA and Dunnett test and log rank test. RESULTS： Compared to FADM or ADM ＋ BL, LADM produced a more significant tumor inhibition （tumor volume ratio： 1.243±0.523 vs 1.883±0.708, 1.847±0.661, P 〈 0.01）, and more extensive tumor necrosis. The increased life span was prolonged significantly in rats receiving LADM compared with FADM or ADM＋BL （231.48 vs 74.66, 94.70） （P 〈 0.05）. CONCLUSION： The anticancer efficacies of adriamycin on hepatoma can be strongly improved by liposomal encapsulation through hepatic arterial administration.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v12.i29.4741