Eradication of H pylori infection in a rural population： One-day quadruple therapy versus 7-day triple therapy

• Published in: World journal of gastroenterology : WJG 2006-06, Vol.12 (24), p.3915-3918
• Main Authors: Zhang, Lian, Shen, Lin, Ma, Jun-Ling, Pan, Kai-Feng, Liu, Wei-Dong, Li, Jie, Xiao, Shu-Dong, Lin, San-Ren, Classen, Meinhard, You, Wei-Cheng
• Format: Article
• Language: English
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Amoxicillin - administration & dosage; Amoxicillin - pharmacology; Amoxicillin - therapeutic use; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Clarithromycin - administration & dosage; Clarithromycin - pharmacology; Clarithromycin - therapeutic use; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Helicobacter Infections - drug therapy; Helicobacter pylori - drug effects; Helicobacter pylori - pathogenicity; Humans; Lansoprazole; Male; Metronidazole - administration & dosage; Metronidazole - pharmacology; Metronidazole - therapeutic use; Middle Aged; Omeprazole - administration & dosage; Omeprazole - analogs & derivatives; Omeprazole - pharmacology; Omeprazole - therapeutic use; Organometallic Compounds - administration & dosage; Organometallic Compounds - pharmacology; Organometallic Compounds - therapeutic use; Pilot Projects; Prospective Studies; Rapid Communication; Rural Population; 幽门螺杆菌; 治疗方法; 细菌感染
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v12.i24.3915

AIM： To compare the one-day quadruple therapy with a standard 7-d triple therapy for H pylori eradication in a rural population of China. METHODS： A total of 396 patients with 13C-urea breath test positive for H pylori were assigned into two groups： 239 patients received one-day quadruple therapy （amoxicillin 2000 mg qid; metronidazole 500 mg qid; bismuth citrate 900 mg qid and lansoprazole 60 mg once daily） and 157 patients received 7-d standard triple therapy （amoxicillin 1000 mg bid; clarithromycin 500 mg bid and lansoprazole 30 mg bid）. All the patients underwent a 13C-UBT to assess the eradication of Hpylori infection six weeks after treatment. RESULTS： Two hundred and twenty-nine patients completed the one-day therapy （95.8%） and 148 patients completed the 7-d therapy （94.2%）. The oneday therapy eradicated H pylori infection in 64 patients （27.95%）. In contrast, 103 patients （69.59%） were Hpylori negative after the 7-d therapy （P 〈 0.01）. CONCLUSION： This pilot study suggests there is no beneficial effect of the one-day therapy in treatment ofHpylori infection compared with the 7-d standard therapy.