Loading…

High Mycoplasma genitalium Organism Burden Is Associated with Shedding of HIV-1 DNA from the Cervix

We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of infectious diseases 2008-03, Vol.197 (5), p.733-736
Main Authors:	Manhart, Lisa E., Mostad, Sara B., Baeten, Jared M., Astete, Sabina G., Mandaliya, Kishorchandra, Totten, Patricia A.
Format:	Article
Language:	English
Subjects:	Adolescent Adult AIDS Bacteriology Biological and medical sciences Cervix Uteri - virology DNA, Viral Female Fundamental and applied biological sciences. Psychology Genitalia HIV HIV 1 HIV Infections - complications HIV/AIDS Human immunodeficiency virus 1 Humans Infections Kenya Microbiology Middle Aged Miscellaneous Mycoplasma genitalium Mycoplasma genitalium - pathogenicity Mycoplasma Infections - complications Neutrophils Odds Ratio Polymerase chain reaction Sexually transmitted diseases Uterine cervicitis Virology Virus Shedding
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c453t-2bbfdc6736d9e764c8a3f49492be36ed0e700a5b3cdfb3d95db3050ca53b8c1e3
cites	cdi_FETCH-LOGICAL-c453t-2bbfdc6736d9e764c8a3f49492be36ed0e700a5b3cdfb3d95db3050ca53b8c1e3
container_end_page	736
container_issue	5
container_start_page	733
container_title	The Journal of infectious diseases
container_volume	197
creator	Manhart, Lisa E. Mostad, Sara B. Baeten, Jared M. Astete, Sabina G. Mandaliya, Kishorchandra Totten, Patricia A.
description	We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in 154 women (51%); M. genitalium was detected by qualitative PCR in 52 (17%), and organism burden was determined by quantitative PCR. Women with high M. genitalium organism burdens (more than the median of 3195 genomes/mL) were 3-fold more likely to shed HIV-1 DNA than were M. genitalium—negative women (adjusted OR, 2.9 [95% confidence interval, 1.1–7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count).
doi_str_mv	10.1086/526501
format	article
fullrecord	<record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4090222</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30087013</jstor_id><sourcerecordid>30087013</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-2bbfdc6736d9e764c8a3f49492be36ed0e700a5b3cdfb3d95db3050ca53b8c1e3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EotsC_wDkC70FxnFsxxek7fKxKwpF4lNcLMd2EpckXuyktP-eoF1t4cRpDs-jd0bzIvSIwDMCJX_Ocs6A3EELwqjIOCf0LloA5HlGSimP0HFKlwBQUC7uoyNS5pxzYAtk1r5p8bsbE7adTr3GjRv8qDs_9fgiNnrwqcdnU7RuwJuElykF4_XoLP7lxxZ_bJ21fmhwqPF68yUj-OX7Ja5j6PHYOrxy8cpfP0D3at0l93A_T9Dn168-rdbZ-cWbzWp5npmC0THLq6q2hgvKrXSCF6bUtC5kIfPKUe4sOAGgWUWNrStqJbMVBQZGM1qVhjh6gl7scrdT1Ttr3DBG3alt9L2ONypor_4lg29VE65UAXL-VD4HnO4DYvg5uTSq3ifjuk4PLkxJcUkIzTn9r0gkF7Ig_FY0MaQUXX24hoD6U5zaFTeLT_6-_VbbNzULT_eCTkZ3ddSD8eng5TD3LEDM3uOdd5nGEA-cApRi3jPzbMd9Gt31gev4Q82vF0ytv31XH8q3Z6X8yhShvwGJw7hB</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19679416</pqid></control><display><type>article</type><title>High Mycoplasma genitalium Organism Burden Is Associated with Shedding of HIV-1 DNA from the Cervix</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Oxford Journals Online</source><creator>Manhart, Lisa E. ; Mostad, Sara B. ; Baeten, Jared M. ; Astete, Sabina G. ; Mandaliya, Kishorchandra ; Totten, Patricia A.</creator><creatorcontrib>Manhart, Lisa E. ; Mostad, Sara B. ; Baeten, Jared M. ; Astete, Sabina G. ; Mandaliya, Kishorchandra ; Totten, Patricia A.</creatorcontrib><description>We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in 154 women (51%); M. genitalium was detected by qualitative PCR in 52 (17%), and organism burden was determined by quantitative PCR. Women with high M. genitalium organism burdens (more than the median of 3195 genomes/mL) were 3-fold more likely to shed HIV-1 DNA than were M. genitalium—negative women (adjusted OR, 2.9 [95% confidence interval, 1.1–7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count).</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/526501</identifier><identifier>PMID: 18266605</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; AIDS ; Bacteriology ; Biological and medical sciences ; Cervix Uteri - virology ; DNA, Viral ; Female ; Fundamental and applied biological sciences. Psychology ; Genitalia ; HIV ; HIV 1 ; HIV Infections - complications ; HIV/AIDS ; Human immunodeficiency virus 1 ; Humans ; Infections ; Kenya ; Microbiology ; Middle Aged ; Miscellaneous ; Mycoplasma genitalium ; Mycoplasma genitalium - pathogenicity ; Mycoplasma Infections - complications ; Neutrophils ; Odds Ratio ; Polymerase chain reaction ; Sexually transmitted diseases ; Uterine cervicitis ; Virology ; Virus Shedding</subject><ispartof>The Journal of infectious diseases, 2008-03, Vol.197 (5), p.733-736</ispartof><rights>Copyright 2007 Infectious Diseases Society of America</rights><rights>2008 INIST-CNRS</rights><rights>2008 by the Infectious Diseases Society of America. All rights reserved. 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-2bbfdc6736d9e764c8a3f49492be36ed0e700a5b3cdfb3d95db3050ca53b8c1e3</citedby><cites>FETCH-LOGICAL-c453t-2bbfdc6736d9e764c8a3f49492be36ed0e700a5b3cdfb3d95db3050ca53b8c1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30087013$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30087013$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20189707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18266605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manhart, Lisa E.</creatorcontrib><creatorcontrib>Mostad, Sara B.</creatorcontrib><creatorcontrib>Baeten, Jared M.</creatorcontrib><creatorcontrib>Astete, Sabina G.</creatorcontrib><creatorcontrib>Mandaliya, Kishorchandra</creatorcontrib><creatorcontrib>Totten, Patricia A.</creatorcontrib><title>High Mycoplasma genitalium Organism Burden Is Associated with Shedding of HIV-1 DNA from the Cervix</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in 154 women (51%); M. genitalium was detected by qualitative PCR in 52 (17%), and organism burden was determined by quantitative PCR. Women with high M. genitalium organism burdens (more than the median of 3195 genomes/mL) were 3-fold more likely to shed HIV-1 DNA than were M. genitalium—negative women (adjusted OR, 2.9 [95% confidence interval, 1.1–7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count).</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cervix Uteri - virology</subject><subject>DNA, Viral</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genitalia</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - complications</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Infections</subject><subject>Kenya</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mycoplasma genitalium</subject><subject>Mycoplasma genitalium - pathogenicity</subject><subject>Mycoplasma Infections - complications</subject><subject>Neutrophils</subject><subject>Odds Ratio</subject><subject>Polymerase chain reaction</subject><subject>Sexually transmitted diseases</subject><subject>Uterine cervicitis</subject><subject>Virology</subject><subject>Virus Shedding</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EotsC_wDkC70FxnFsxxek7fKxKwpF4lNcLMd2EpckXuyktP-eoF1t4cRpDs-jd0bzIvSIwDMCJX_Ocs6A3EELwqjIOCf0LloA5HlGSimP0HFKlwBQUC7uoyNS5pxzYAtk1r5p8bsbE7adTr3GjRv8qDs_9fgiNnrwqcdnU7RuwJuElykF4_XoLP7lxxZ_bJ21fmhwqPF68yUj-OX7Ja5j6PHYOrxy8cpfP0D3at0l93A_T9Dn168-rdbZ-cWbzWp5npmC0THLq6q2hgvKrXSCF6bUtC5kIfPKUe4sOAGgWUWNrStqJbMVBQZGM1qVhjh6gl7scrdT1Ttr3DBG3alt9L2ONypor_4lg29VE65UAXL-VD4HnO4DYvg5uTSq3ifjuk4PLkxJcUkIzTn9r0gkF7Ig_FY0MaQUXX24hoD6U5zaFTeLT_6-_VbbNzULT_eCTkZ3ddSD8eng5TD3LEDM3uOdd5nGEA-cApRi3jPzbMd9Gt31gev4Q82vF0ytv31XH8q3Z6X8yhShvwGJw7hB</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Manhart, Lisa E.</creator><creator>Mostad, Sara B.</creator><creator>Baeten, Jared M.</creator><creator>Astete, Sabina G.</creator><creator>Mandaliya, Kishorchandra</creator><creator>Totten, Patricia A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080301</creationdate><title>High Mycoplasma genitalium Organism Burden Is Associated with Shedding of HIV-1 DNA from the Cervix</title><author>Manhart, Lisa E. ; Mostad, Sara B. ; Baeten, Jared M. ; Astete, Sabina G. ; Mandaliya, Kishorchandra ; Totten, Patricia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-2bbfdc6736d9e764c8a3f49492be36ed0e700a5b3cdfb3d95db3050ca53b8c1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Cervix Uteri - virology</topic><topic>DNA, Viral</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genitalia</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Infections - complications</topic><topic>HIV/AIDS</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Infections</topic><topic>Kenya</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mycoplasma genitalium</topic><topic>Mycoplasma genitalium - pathogenicity</topic><topic>Mycoplasma Infections - complications</topic><topic>Neutrophils</topic><topic>Odds Ratio</topic><topic>Polymerase chain reaction</topic><topic>Sexually transmitted diseases</topic><topic>Uterine cervicitis</topic><topic>Virology</topic><topic>Virus Shedding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manhart, Lisa E.</creatorcontrib><creatorcontrib>Mostad, Sara B.</creatorcontrib><creatorcontrib>Baeten, Jared M.</creatorcontrib><creatorcontrib>Astete, Sabina G.</creatorcontrib><creatorcontrib>Mandaliya, Kishorchandra</creatorcontrib><creatorcontrib>Totten, Patricia A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manhart, Lisa E.</au><au>Mostad, Sara B.</au><au>Baeten, Jared M.</au><au>Astete, Sabina G.</au><au>Mandaliya, Kishorchandra</au><au>Totten, Patricia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Mycoplasma genitalium Organism Burden Is Associated with Shedding of HIV-1 DNA from the Cervix</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>197</volume><issue>5</issue><spage>733</spage><epage>736</epage><pages>733-736</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in 154 women (51%); M. genitalium was detected by qualitative PCR in 52 (17%), and organism burden was determined by quantitative PCR. Women with high M. genitalium organism burdens (more than the median of 3195 genomes/mL) were 3-fold more likely to shed HIV-1 DNA than were M. genitalium—negative women (adjusted OR, 2.9 [95% confidence interval, 1.1–7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count).</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>18266605</pmid><doi>10.1086/526501</doi><tpages>4</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0022-1899
ispartof	The Journal of infectious diseases, 2008-03, Vol.197 (5), p.733-736
issn	0022-1899 1537-6613
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4090222
source	JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online
subjects	Adolescent Adult AIDS Bacteriology Biological and medical sciences Cervix Uteri - virology DNA, Viral Female Fundamental and applied biological sciences. Psychology Genitalia HIV HIV 1 HIV Infections - complications HIV/AIDS Human immunodeficiency virus 1 Humans Infections Kenya Microbiology Middle Aged Miscellaneous Mycoplasma genitalium Mycoplasma genitalium - pathogenicity Mycoplasma Infections - complications Neutrophils Odds Ratio Polymerase chain reaction Sexually transmitted diseases Uterine cervicitis Virology Virus Shedding
title	High Mycoplasma genitalium Organism Burden Is Associated with Shedding of HIV-1 DNA from the Cervix
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T09%3A45%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20Mycoplasma%20genitalium%20Organism%20Burden%20Is%20Associated%20with%20Shedding%20of%20HIV-1%20DNA%20from%20the%20Cervix&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Manhart,%20Lisa%20E.&rft.date=2008-03-01&rft.volume=197&rft.issue=5&rft.spage=733&rft.epage=736&rft.pages=733-736&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/526501&rft_dat=%3Cjstor_pubme%3E30087013%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c453t-2bbfdc6736d9e764c8a3f49492be36ed0e700a5b3cdfb3d95db3050ca53b8c1e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=19679416&rft_id=info:pmid/18266605&rft_jstor_id=30087013&rfr_iscdi=true