Smoking and choroidal thickness in patients over 65 with early-atrophic age-related macular degeneration and normals

Objective To compare macular choroidal thickness between cigarette smokers, those with a history of smoking, and nonsmokers in patients over 65 years of age with early-atrophic age-related macular degeneration (AMD) and normals. Methods Prospective, consecutive, observational case series. Enhanced d...

Full description

Saved in:
Bibliographic Details
Published in:Eye (London) 2014-07, Vol.28 (7), p.838-846
Main Authors: Sigler, E J, Randolph, J C, Calzada, J I, Charles, S
Format: Article
Language:English
Subjects:
631/378/1689/1626
692/499
692/699/3161/3175
Aged
Aged, 80 and over
Choroid - pathology
Clinical Study
Early Diagnosis
Fluorescein Angiography
Geographic Atrophy - diagnosis
Humans
Laboratory Medicine
Macula Lutea
Medicine
Medicine & Public Health
Ophthalmology
Organ Size
Pharmaceutical Sciences/Technology
Prospective Studies
Risk Factors
Smoking - adverse effects
Surgery
Surgical Oncology
Tomography, Optical Coherence
Visual Acuity
Wet Macular Degeneration - diagnosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To compare macular choroidal thickness between cigarette smokers, those with a history of smoking, and nonsmokers in patients over 65 years of age with early-atrophic age-related macular degeneration (AMD) and normals. Methods Prospective, consecutive, observational case series. Enhanced depth imaging spectral domain optical coherence tomography 12-line radial scans were performed and choroidal thickness manually quantified at 84 points in the central 3 mm of the macula. Data of normals, soft drusen alone, and soft drusen with additional features of early AMD were compared. A multivariate analysis of variance (MANOVA) model, controlling for age, was constructed to evaluate the effect of smoking history and AMD features on choroidal thickness. Results A history of smoking was significantly associated with a thinner choroid across all patients via logistic regression ( P =0.004; O.R.=12.4). Mean macular choroidal thickness was thinner for smokers (148±63  μ m) than for nonsmokers (181±65  μ m) among all diagnosis categories ( P =0.003). Subgroup analysis of patients with AMD features revealed a similar decreased choroidal thickness in smokers (121±41  μ m) compared with nonsmokers (146±46  μ m, P =0.006). Bivariate analysis revealed an association between increased pack-years of smoking and a thin choroid across all patients ( P
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2014.100