Functions of caspase 8: The identified and the mysterious

Highlights • Caspase-8 is required for death receptor apoptosis and, paradoxically, survival of some cell types. • This switch requires protein kinases of the RIP family, which engage a pathway known as necroptosis. • The pro-apoptotic and pro-survival functions of caspase-8 are regulated by the pse...

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Bibliographic Details
Published in:Seminars in immunology 2014-06, Vol.26 (3), p.246-252
Main Authors: Salvesen, Guy S, Walsh, Craig M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Apoptosis
Autophagy
Caspase 8 - physiology
Cell Death
Cell Survival
Humans
Necroptosis
Necrosis
Signal Transduction
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Summary:Highlights • Caspase-8 is required for death receptor apoptosis and, paradoxically, survival of some cell types. • This switch requires protein kinases of the RIP family, which engage a pathway known as necroptosis. • The pro-apoptotic and pro-survival functions of caspase-8 are regulated by the pseudo-caspase cFLIP. • The mechanism of how caspase-8 and cFLIP coordinate the switch between apoptosis and survival is unknown. • The reason why an apoptotic initiator has been co-opted as a critical survival factor is unknown.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2014.03.005