Astrocytes, but not microglia, are activated in oxaliplatin and bortezomib-induced peripheral neuropathy in the rat

Highlights • Chemotherapy causes mechanical hypersensitivity and activated astrocytes. • Microglia were not activated by chemotherapy but were by spinal nerve ligation. • Astrocyte activation and mechanical sensitivity were prevented with minocycline.

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Bibliographic Details
Published in:Neuroscience 2014-08, Vol.274, p.308-317
Main Authors: Robinson, C.R, Zhang, H, Dougherty, P.M
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - toxicity
astrocytes
Astrocytes - drug effects
Astrocytes - pathology
Astrocytes - physiology
Biological and medical sciences
Boronic Acids - toxicity
Bortezomib
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Fundamental and applied biological sciences. Psychology
Glial Fibrillary Acidic Protein - metabolism
Hyperalgesia - chemically induced
Hyperalgesia - drug therapy
Hyperalgesia - pathology
Hyperalgesia - physiopathology
Male
Medical sciences
microglia
Microglia - drug effects
Microglia - pathology
Microglia - physiology
minocycline
Minocycline - pharmacology
Nervous system (semeiology, syndromes)
Neurology
Neuroprotective Agents - pharmacology
Organoplatinum Compounds - toxicity
oxaliplatin
Peripheral Nervous System Diseases - chemically induced
Peripheral Nervous System Diseases - drug therapy
Peripheral Nervous System Diseases - pathology
Peripheral Nervous System Diseases - physiopathology
Pyrazines - toxicity
Rats, Sprague-Dawley
Spinal Cord - drug effects
Spinal Cord - pathology
Spinal Cord - physiopathology
Spinal Nerves - injuries
Vertebrates: nervous system and sense organs
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Description
Summary:Highlights • Chemotherapy causes mechanical hypersensitivity and activated astrocytes. • Microglia were not activated by chemotherapy but were by spinal nerve ligation. • Astrocyte activation and mechanical sensitivity were prevented with minocycline.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.05.051