Advance in ERG Analysis : From Peak Time and Amplitude to Frequency, Power, and Energy

Purpose. To compare time domain (TD: peak time and amplitude) analysis of the human photopic electroretinogram (ERG) with measures obtained in the frequency domain (Fourier analysis: FA) and in the time-frequency domain (continuous (CWT) and discrete (DWT) wavelet transforms). Methods. Normal ERGs n...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-11
Main Authors: Gauvin, Mathieu, Lachapelle, Pierre, Lina, Jean-Marc
Format: Article
Language:English
Subjects:
Adult
Biomedical research
Electrocardiography
Electroencephalography
Electroretinography
Electroretinography - methods
Female
Forecasts and trends
Fourier analysis
Humans
Male
Medical research
Methods
Models, Theoretical
Physiological aspects
Retina
Retina - physiopathology
Retinal Diseases - diagnosis
Retinal Diseases - physiopathology
Studies
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Summary:Purpose. To compare time domain (TD: peak time and amplitude) analysis of the human photopic electroretinogram (ERG) with measures obtained in the frequency domain (Fourier analysis: FA) and in the time-frequency domain (continuous (CWT) and discrete (DWT) wavelet transforms). Methods. Normal ERGs n=40 were analyzed using traditional peak time and amplitude measurements of the a- and b-waves in the TD and descriptors extracted from FA, CWT, and DWT. Selected descriptors were also compared in their ability to monitor the long-term consequences of disease process. Results. Each method extracted relevant information but had distinct limitations (i.e., temporal and frequency resolutions). The DWT offered the best compromise by allowing us to extract more relevant descriptors of the ERG signal at the cost of lesser temporal and frequency resolutions. Follow-ups of disease progression were more prolonged with the DWT (max 29 years compared to 13 with TD). Conclusions. Standardized time domain analysis of retinal function should be complemented with advanced DWT descriptors of the ERG. This method should allow more sensitive/specific quantifications of ERG responses, facilitate follow-up of disease progression, and identify diagnostically significant changes of ERG waveforms that are not resolved when the analysis is only limited to time domain measurements.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/246096