Hypertrophic lupus erythematosus: the diagnostic utility of CD123 staining

CD123‐positive plasmacytoid dendrocytes are prominent in the infiltrate of discoid lupus erythematosus (LE). We hypothesized that these cells would also be present in hypertrophic LE and would aid in the histopathologic distinction from squamous cell carcinoma (SCC) and hypertrophic actinic keratosi...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2011-11, Vol.38 (11), p.889-892
Main Authors: Ko, Christine J., Srivastava, Bhaskar, Braverman, Irwin, Antaya, Richard J., McNiff, Jennifer M.
Format: Article
Language:English
Subjects:
actinic keratosis
Adult
Biological and medical sciences
Biomarkers - metabolism
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
CD123
Dendritic Cells - metabolism
Dendritic Cells - pathology
Dermatology
Diagnosis, Differential
Female
Humans
Hypertrophy - pathology
Interleukin-3 Receptor alpha Subunit - metabolism
keratoacanthoma
Keratosis, Actinic - diagnosis
Keratosis, Actinic - metabolism
lupus erythematosus
Lupus Erythematosus, Discoid - diagnosis
Lupus Erythematosus, Discoid - metabolism
Male
Medical sciences
Middle Aged
Retrospective Studies
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Skin - metabolism
Skin - pathology
Skin Neoplasms - diagnosis
Skin Neoplasms - metabolism
squamous cell carcinoma
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Summary:CD123‐positive plasmacytoid dendrocytes are prominent in the infiltrate of discoid lupus erythematosus (LE). We hypothesized that these cells would also be present in hypertrophic LE and would aid in the histopathologic distinction from squamous cell carcinoma (SCC) and hypertrophic actinic keratosis (AK). Five cases of hypertrophic LE and 10 cases each of SCC and hypertrophic AK were stained with CD123. A heavy band of CD123‐positive cells was present at the epidermal–dermal junction in all cases of hypertrophic LE, and only single or rare scattered clusters of CD123‐positive cells were seen in SCC and actinic keratoses. The pattern of CD123 staining can be a useful feature to distinguish hypertrophic LE from SCC and hypertrophic AK. Ko CJ, Srivastava B, Braverman I, Antaya RJ, McNiff JM. Hypertrophic lupus erythematosus: the diagnostic utility of CD123 staining.
ISSN:0303-6987
1600-0560
DOI:10.1111/j.1600-0560.2011.01779.x