Novel signaling mechanisms in the ovary during oocyte maturation and ovulation

► cAMP signaling controls MPF and prevents cell cycle reentry in the oocyte. ► cGMP signaling intersects with cAMP signaling to control meiotic arrest. ► The ovulatory LH signal activates multiple signaling pathways in the follicle. ► LH signals are propagated through the ovulatory follicle via rele...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2012-06, Vol.356 (1-2), p.65-73
Main Authors: Conti, Marco, Hsieh, Minnie, Musa Zamah, A., Oh, Jeong Su
Format: Article
Language:English
Subjects:
Activation
Animals
cAMP
cell cycle
Compartments
eggs
Endocrinology
Female
Focusing
Gap Junctions - metabolism
Gene expression
gene expression regulation
Gonadotropins
Humans
Intracellular Signaling Peptides and Proteins - metabolism
luteinizing hormone
Luteinizing Hormone - metabolism
Luteinizing Hormone - physiology
Maturation
Meiosis
Nucleotides, Cyclic - metabolism
Nucleotides, Cyclic - physiology
Oocyte
oocytes
Oocytes - metabolism
Oocytes - physiology
ovarian follicles
Ovary
Ovary - cytology
Ovary - metabolism
ovulation
Ovulation - metabolism
Pathways
Receptors, G-Protein-Coupled - metabolism
secretion
Secretions
Signal Transduction
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Summary:► cAMP signaling controls MPF and prevents cell cycle reentry in the oocyte. ► cGMP signaling intersects with cAMP signaling to control meiotic arrest. ► The ovulatory LH signal activates multiple signaling pathways in the follicle. ► LH signals are propagated through the ovulatory follicle via release of paracrine factors. During the peri-ovulatory period, the gonadotropin LH triggers major changes in both the somatic and germ cell compartments of the ovarian follicle. The oocyte completes the meiotic cell cycle to become a fertilizable egg, and dramatic changes in gene expression and secretion take place in the somatic compartment of the follicle in preparation for follicular rupture and oocyte release. The concerted changes are regulated by activation of intracellular signaling pathways as well as paracrine and autocrine regulatory loops. This review will provide a summary of the current knowledge of the molecular events triggered by LH focusing mostly on the signaling pathways required for oocyte maturation.
ISSN:0303-7207
1872-8057
DOI:10.1016/j.mce.2011.11.002