Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report

Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML...

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Bibliographic Details
Published in:Case reports in oncology 2014-06, Vol.7 (2), p.407-409
Main Authors: Trosclair, Christopher, Pollen, Maressa, Capraro, Gerald, Cotelingam, James, Shackelford, Rodney E.
Format: Article
Language:English
Subjects:
Acute myelogenous leukemia without maturation
Acute promyelocytic leukemia
AML-M1
AML-M3
Deletion
PML/RAR?
Published: June 2014
t(15
17)(q22
q21)
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Summary:Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML) subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype.
ISSN:1662-6575
1662-6575
DOI:10.1159/000365002