Subthalamic Nucleus Deep Brain Stimulation Induces Motor Network BOLD Activation: Use of a High Precision MRI Guided Stereotactic System for Nonhuman Primates

Abstract Background Functional magnetic resonance imaging (fMRI) is a powerful method for identifying in vivo network activation evoked by deep brain stimulation (DBS). Objective Identify the global neural circuitry effect of subthalamic nucleus (STN) DBS in nonhuman primates (NHP). Method An in-hou...

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Bibliographic Details
Published in:Brain stimulation 2014-07, Vol.7 (4), p.603-607
Main Authors: Min, Hoon-Ki, Ross, Erika K, Lee, Kendall H, Dennis, Kendall, Han, Seong Rok, Jeong, Ju Ho, Marsh, Michael P, Striemer, Bryan, Felmlee, Joel P, Lujan, J. Luis, Goerss, Steve, Duffy, Penelope S, Blaha, Charles D, Chang, Su-Youne, Bennet, Kevin E
Format: Article
Language:English
Subjects:
Animals
Basal Ganglia - physiology
Caudate Nucleus - physiology
Cerebellum - physiology
Deep Brain Stimulation
Functional magnetic resonance imaging
Gyrus Cinguli - physiology
Macaca mulatta
Magnetic Resonance Imaging - methods
Male
Motor cortex
Motor Cortex - physiology
Neural Pathways
Neurology
Nonhuman primate
Oxygen - blood
Pedunculopontine nucleus
Pedunculopontine Tegmental Nucleus - physiology
Sensorimotor Cortex - physiology
Stereotaxic Techniques
Subthalamic nucleus
Subthalamic Nucleus - physiology
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Summary:Abstract Background Functional magnetic resonance imaging (fMRI) is a powerful method for identifying in vivo network activation evoked by deep brain stimulation (DBS). Objective Identify the global neural circuitry effect of subthalamic nucleus (STN) DBS in nonhuman primates (NHP). Method An in-house developed MR image-guided stereotactic targeting system delivered a mini-DBS stimulating electrode, and blood oxygenation level-dependent (BOLD) activation during STN DBS in healthy NHP was measured by combining fMRI with a normalized functional activation map and general linear modeling. Results STN DBS significantly increased BOLD activation in the sensorimotor cortex, supplementary motor area, caudate nucleus, pedunculopontine nucleus, cingulate, insular cortex, and cerebellum (FDR 
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2014.04.007