Regenerative medicine: transforming the drug discovery and development paradigm

Despite the explosion of knowledge in basic biological processes controlling tissue regeneration and the growing interest in repairing/replacing diseased tissues and organs through various approaches (e.g., small and large molecule therapeutics, stem cell injection, tissue engineering), the pharmace...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2014-08, Vol.4 (8), p.a014084-a014084
Main Author: Karathanasis, Sotirios K
Format: Article
Language:English
Subjects:
Cell- and Tissue-Based Therapy - methods
Cell- and Tissue-Based Therapy - trends
Drug Discovery - methods
Drug Discovery - trends
Drug Evaluation, Preclinical - methods
Drug Evaluation, Preclinical - trends
Drug Industry
Drug-Related Side Effects and Adverse Reactions - prevention & control
Humans
Intercellular Signaling Peptides and Proteins - physiology
Regenerative Medicine - methods
Regenerative Medicine - trends
Stem Cell Research
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Summary:Despite the explosion of knowledge in basic biological processes controlling tissue regeneration and the growing interest in repairing/replacing diseased tissues and organs through various approaches (e.g., small and large molecule therapeutics, stem cell injection, tissue engineering), the pharmaceutical industry (pharma) has been reluctant to fully adopt these technologies into the traditional drug discovery and research and development (R&D) process. In this article, I discuss knowledge-base gaps and other possible factors that may delay full incorporation of these innovations in pharma R&D. I hope that this discussion will illuminate key issues that currently limit synergistic relationships between pharma and academic institutions and may even stimulate initiation of such collaborative research.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a014084