Similarity of GATA-3 Expression between Rat and Human Mammary Glands

The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2014, Vol.27(2), pp.159-162
Main Authors: Kinoshita, Yuichi, Yoshizawa, Katsuhiko, Emoto, Yuko, Yuki, Michiko, Yuri, Takashi, Shikata, Nobuaki, Tsubura, Airo
Format: Article
Language:English
Subjects:
GATA-3
immunohistochemistry
mammary gland
mammary tumor
rats
Short Communication
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Summary:The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal mammary glands, fibroadenomas and carcinomas was immunohistochemically compared in female rats and humans. In normal mammary glands of rats and humans, scattered luminal cells in the acini and whole ductal epithelial cells were positive for GATA-3 in the nuclei. No positive cells were detected in rat or human fibroadenomas. In rat and human mammary carcinomas, the nuclei of proliferating luminal-derived cancer cells expressed GATA-3. Therefore, GATA-3 protein is a candidate marker for mammary carcinoma in rats as well as humans.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2014-0008