Dengue Human Infection Model Performance Parameters

Dengue is a global health problem and of concern to travelers and deploying military personnel with development and licensure of an effective tetravalent dengue vaccine a public health priority. The dengue viruses (DENVs) are mosquito-borne flaviviruses transmitted by infected Aedes mosquitoes. Illn...

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Bibliographic Details
Published in:The Journal of infectious diseases 2014-06, Vol.209 (suppl 2), p.S56-S60
Main Author: Endy, Timothy P.
Format: Article
Language:English
Subjects:
Aedes - virology
Animals
Arboviroses
Attenuated vaccines
Biological and medical sciences
Dengue
Dengue - immunology
Dengue - prevention & control
Dengue fevers
Dengue Human Infection Model
Dengue vaccines
Dengue Vaccines - immunology
Dengue Virus
Disease models
Fever
Fundamental and applied biological sciences. Psychology
Hospitalization
Human viral diseases
Humans
Infections
Infectious diseases
Influenza vaccines
Medical sciences
Microbiology
Models, Biological
Public Health
Symptoms
Tropical viral diseases
Viral diseases
Viruses
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Summary:Dengue is a global health problem and of concern to travelers and deploying military personnel with development and licensure of an effective tetravalent dengue vaccine a public health priority. The dengue viruses (DENVs) are mosquito-borne flaviviruses transmitted by infected Aedes mosquitoes. Illness manifests across a clinical spectrum with severe disease characterized by intravascular volume depletion and hemorrhage. DENV illness results from a complex interaction of viral properties and host immune responses. Dengue vaccine development efforts are challenged by immunologie complexity, lack of an adequate animal model of disease, absence of an immune correlate of protection, and only partially informative immunogenicity assays. A dengue human infection model (DHIM) will be an essential tool in developing potential dengue vaccines or antivirale. The potential performance parameters needed for a DHIM to support vaccine or antiviral candidates are discussed.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiu112