Dendrobium candidum Wall. ex Lindl. attenuates CCl4-induced hepatic damage in imprinting control region mice

The aim of the present study was to determine the preventive effect of the traditional Chinese medicine, Dendrobium candidum Wall ex Lindl. (D. candidum), on CCl4-induced hepatic damage in mice. The CCl4-induced hepatic damage mice were treated with D. candidum, and the serum levels of aspartate ami...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2014-09, Vol.8 (3), p.1015-1021
Main Authors: LI, GUI-JIE, SUN, PENG, WANG, QIANG, QIAN, YU, ZHU, KAI, ZHAO, XIN
Format: Article
Language:English
Subjects:
Bile
Biological products
Cholesterol
cytokine
Cytokines
Dehydrogenases
Dendrobium candidum
Disease prevention
gene
Gene expression
hepatic damage
imprinting control region mice
Inflammation
Liver cancer
Liver diseases
Rodents
Tumor necrosis factor-TNF
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Summary:The aim of the present study was to determine the preventive effect of the traditional Chinese medicine, Dendrobium candidum Wall ex Lindl. (D. candidum), on CCl4-induced hepatic damage in mice. The CCl4-induced hepatic damage mice were treated with D. candidum, and the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), triglyceride (TG) and total cholesterol (TC) were determined. In addition, serum cytokine levels of interleukin (IL)-6, IL-12, tumor necrosis factor (TNF)-α and interferon (IFN)-γ were analyzed with kits, while liver tissues were analyzed using hematoxylin and eosin staining and reverse transcription polymerase chain reaction (RT-PCR). Furthermore, the contents of D. candidum were determined by nuclear magnetic resonance (NMR). D. candidum was demonstrated to successfully prevent hepatic damage in mice. The serum levels of AST, ALT and LDH were significantly decreased when the mice were treated with 200 and 400 mg/kg D. candidum, as compared with the control mice (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2014.1834