Obesity, central adiposity and cardiometabolic risk factors in children and adolescents: a family-based study

Summary Objective The objective of this study was to assess genetic and phenotypic correlations of obesity‐related cardiometabolic risk factors in a family‐based cohort. Methods Anthropometric, body composition and biochemical measurements were collected on 999 members of 111 extended Midwestern US...

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Bibliographic Details
Published in:Pediatric obesity 2014-06, Vol.9 (3), p.e58-e62
Main Authors: Ali, O., Cerjak, D., Kent Jr, J. W., James, R., Blangero, J., Zhang, Y.
Format: Article
Language:English
Subjects:
Adolescent
Adolescent obesity
Adult
Body Composition
Body fat
Body Mass Index
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - prevention & control
central adiposity
Child
Childrens health
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cohort Studies
dyslipidaemia
Female
Humans
Insulin Resistance
Low density lipoprotein
Male
Metabolic Syndrome - epidemiology
Metabolic Syndrome - etiology
Metabolic Syndrome - prevention & control
Obesity
Obesity, Abdominal - complications
Obesity, Abdominal - epidemiology
Obesity, Abdominal - prevention & control
Pediatrics
Phenotype
Predictive Value of Tests
Risk Assessment
Risk Factors
Teenagers
Triglycerides - blood
Waist Circumference
White People - statistics & numerical data
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Summary:Summary Objective The objective of this study was to assess genetic and phenotypic correlations of obesity‐related cardiometabolic risk factors in a family‐based cohort. Methods Anthropometric, body composition and biochemical measurements were collected on 999 members of 111 extended Midwestern US families of Northern European origin. Forward stepwise regression was used to identify which of Tanner stage, sex, Tanner stage by sex, body fat mass index, body fat percentage (dual‐energy X‐ray absorptiometry), visceral fat (VF)/subcutaneous fat (SubQF) (computed tomography scans for adults or magnetic resonance imaging for children), VF, SubQF, body mass index (BMI)% and waist to height ratio most influence homeostasis model assessment (HOMA), high‐density lipoprotein cholesterol (HDL‐c), plasma triglycerides (TG) and low‐density lipoprotein cholesterol (LDL‐c). Results In children and adolescents, subcutaneous adiposity was the most significant covariate for HOMA (P 
ISSN:2047-6302
2047-6310
2047-6310
DOI:10.1111/j.2047-6310.2014.218.x