Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery

Binding interactions between DNA and cationic carriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and -nitrobenzyl moieties that facilitated tailorable DNA complexation and l...

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Bibliographic Details
Published in:Polymer chemistry 2014-06, Vol.5 (19), p.5535-5541
Main Authors: Green, Matthew D, Foster, Abbygail A, Greco, Chad T, Roy, Raghunath, Lehr, Rachel M, Epps, 3rd, Thomas H, Sullivan, Millicent O
Format: Article
Language:English
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Summary:Binding interactions between DNA and cationic carriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and -nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to advance non-viral gene packaging.
ISSN:1759-9954
1759-9962
DOI:10.1039/c4py00638k