MDSCs: the final frontier of the microenvironment in CLL?

In this issue of Blood, Jitschin et al identify increased numbers of myeloid-derived suppressor cells (MDSCs) in untreated patients with chronic lymphocytic leukemia (CLL) suppressing T cells and inducing regulatory T cells (T(regs)), resulting in impaired immune responses.

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Bibliographic Details
Published in:Blood 2014-07, Vol.124 (5), p.666-668
Main Author: Zirlik, Katja
Format: Article
Language:English
Subjects:
Female
Humans
Inside
Leukemia, Lymphocytic, Chronic, B-Cell - immunology
Lymphocyte Activation
Male
Myeloid Cells - immunology
T-Lymphocytes, Regulatory - immunology
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Description
Summary:In this issue of Blood, Jitschin et al identify increased numbers of myeloid-derived suppressor cells (MDSCs) in untreated patients with chronic lymphocytic leukemia (CLL) suppressing T cells and inducing regulatory T cells (T(regs)), resulting in impaired immune responses.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2014-06-578880