Effect of aging on microRNAs and regulation of pathogen recognition receptors

Highlights • Short non-coding microRNAs regulate gene expression and immune responses. • Dysregulation of pathogen recognition receptors and responses occurs in aging. • MiRNAs that modulate immune functions can change during aging. • Aging-associated miRNAs target pro-inflammatory networks such as...

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Bibliographic Details
Published in:Current opinion in immunology 2014-08, Vol.29, p.29-37
Main Authors: Olivieri, Fabiola, Procopio, Antonio Domenico, Montgomery, Ruth R
Format: Article
Language:English
Subjects:
Adaptive Immunity
Aging
Allergy and Immunology
Animals
Humans
Immunity, Innate
Inflammation - immunology
MicroRNAs - genetics
MicroRNAs - immunology
Receptors, Immunologic - immunology
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Summary:Highlights • Short non-coding microRNAs regulate gene expression and immune responses. • Dysregulation of pathogen recognition receptors and responses occurs in aging. • MiRNAs that modulate immune functions can change during aging. • Aging-associated miRNAs target pro-inflammatory networks such as NF-κB. • Aging-associated miRNAs could be therapeutic targets in immunosensecence.
ISSN:0952-7915
1879-0372
1879-0372
DOI:10.1016/j.coi.2014.03.006