Ameliorative Effect of Saffron Aqueous Extract on Hyperglycemia, Hyperlipidemia, and Oxidative Stress on Diabetic Encephalopathy in Streptozotocin Induced Experimental Diabetes Mellitus

Diabetic encephalopathy is one of the severe complications in patients with diabetes mellitus. Findings indicate that saffron extract has antioxidant properties but its underlying beneficial effects on diabetic encephalopathy were unclear. In the present study, the protective activities of saffron w...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-12
Main Authors: Samarghandian, Saeed, Azimi-Nezhad, Mohsen, Samini, Fariborz
Format: Article
Language:English
Subjects:
Animal cognition
Animals
Antioxidants
Behavior, Animal - drug effects
Body Weight - drug effects
Brain Diseases - drug therapy
Brain research
Care and treatment
Colleges & universities
Complications and side effects
Crocus - chemistry
Diabetes
Diabetes Mellitus, Experimental - complications
Enzymes
Glycation End Products, Advanced - blood
Herbal medicine
Hippocampus - chemistry
Hippocampus - drug effects
Hippocampus - enzymology
Hyperglycemia
Hyperglycemia - drug therapy
Hyperlipidemia
Hyperlipidemias - drug therapy
Lipids - blood
Male
Materia medica, Vegetable
Maze Learning - drug effects
Medicine
Mortality
Oxidative stress
Oxidative Stress - drug effects
Plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Protective Agents - chemistry
Protective Agents - pharmacology
Protective Agents - therapeutic use
Rats
Rats, Wistar
Rodents
Saffron crocus
Streptozocin
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetic encephalopathy is one of the severe complications in patients with diabetes mellitus. Findings indicate that saffron extract has antioxidant properties but its underlying beneficial effects on diabetic encephalopathy were unclear. In the present study, the protective activities of saffron were evaluated in diabetic encephalopathy. Saffron at 40 and 80 mg/kg significantly increased body weight and serum TNF-α and decreased blood glucose levels, glycosylated serum proteins, and serum advanced glycation endproducts (AGEs) levels. Furthermore, significant increase in HDL and decrease (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/920857