Brain development in children with new onset epilepsy: A prospective controlled cohort investigation

• Published in: Epilepsia (Copenhagen) 2010-10, Vol.51 (10), p.2038-2046
• Main Authors: Hermann, Bruce P., Dabbs, Kevin, Becker, Tara, Jones, Jana E., Myers y Gutierrez, Adan, Wendt, Gary, Koehn, Monica A., Sheth, Raj, Seidenberg, Michael
• Format: Article
• Language: English
• Subjects: Adolescent; Age of Onset; Anticonvulsants. Antiepileptics. Antiparkinson agents; Atrophy - pathology; Biological and medical sciences; Brain - growth & development; Brain - pathology; Cerebral Cortex - growth & development; Cerebral Cortex - pathology; Child; Cohort Studies; Epilepsy; Epilepsy - diagnosis; Epilepsy - pathology; Female; Frontal Lobe - growth & development; Frontal Lobe - pathology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Longitudinal; Longitudinal Studies; Magnetic Resonance Imaging - statistics & numerical data; Male; Medical sciences; MRI; Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Parietal Lobe - growth & development; Parietal Lobe - pathology; Pharmacology. Drug treatments; Prospective Studies
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1111/j.1528-1167.2010.02563.x

Summary Purpose:  To characterize prospective neurodevelopmental changes in brain structure in children with new and recent‐onset epilepsy compared to healthy controls. Methods:  Thirty‐four healthy controls (mean age 12.9 years) and 38 children with new/recent‐onset idiopathic epilepsy (mean age 12.9 years) underwent 1.5 T magnetic resonance imaging (MRI) at baseline and 2 years later. Prospective changes in total cerebral and lobar gray and white matter volumes were compared within and between groups. Results:  Prospective changes in gray matter volume were comparable for the epilepsy and control groups, with significant (p