Impact of Vitamin D3 Dietary Supplement Matrix on Clinical Response

Context: As a result of research suggesting increased health risk with low serum 25-hydroxycholecalciferol (25(OH)D), health care providers are measuring it frequently. Providers and patients are faced with treatment choices when low status is identified. Objective: To compare the safety and efficac...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2014-08, Vol.99 (8), p.2720-2728
Main Authors: Traub, Michael L, Finnell, John S, Bhandiwad, Anup, Oberg, Erica, Suhaila, Lena, Bradley, Ryan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Cholecalciferol - administration & dosage
Cholecalciferol - adverse effects
Dietary Supplements - adverse effects
Dosage Forms
Dose-Response Relationship, Drug
Drug Administration Routes
Endocrine Care
Endocrinopathies
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Medical sciences
Middle Aged
Treatment Outcome
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - epidemiology
Young Adult
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Summary:Context: As a result of research suggesting increased health risk with low serum 25-hydroxycholecalciferol (25(OH)D), health care providers are measuring it frequently. Providers and patients are faced with treatment choices when low status is identified. Objective: To compare the safety and efficacy of three vitamin D3 dietary supplements with different delivery matrices. Setting and Design: A 12-week, parallel group, single-masked, clinical trial was conducted in Seattle, Washington and Kailua Kona, Hawaii. Sixty-six healthy adults with (25(OH)D)
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2013-3162