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Differences in the reinstatement of ethanol seeking with ganaxolone and gaboxadol

Highlights • A GABAA receptor-active neurosteroid analog, ganaxolone, reinstated ethanol seeking in mice. • An extrasynaptic GABAA receptor agonist, gaboxadol (THIP), did not reinstate ethanol seeking. • Direct extrasynaptic GABAA receptor activation is not sufficient to reinstate ethanol seeking....

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Bibliographic Details
Published in:Neuroscience 2014-07, Vol.272, p.180-187
Main Authors: Ramaker, M.J, Ford, M.M, Phillips, T.J, Finn, D.A
Format: Article
Language:English
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Summary:Highlights • A GABAA receptor-active neurosteroid analog, ganaxolone, reinstated ethanol seeking in mice. • An extrasynaptic GABAA receptor agonist, gaboxadol (THIP), did not reinstate ethanol seeking. • Direct extrasynaptic GABAA receptor activation is not sufficient to reinstate ethanol seeking.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.04.065