Levels of serologic markers of celiac disease in patients with reflux esophagitis

To investigate the prevalence of celiac disease serologic markers (antigliadin IgA, IgG, and anti-endomysial IgA) in patients with reflux esophagitis and to detect the relationship between reflux esophagitis and celiac disease (CD). This study was performed prospectively between January 2003 and Jan...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2006-11, Vol.12 (41), p.6707-6710
Main Authors: Bagci, Sait, Ercin, C Nuri, Yesilova, Zeki, Ozcan, Ayhan, Degertekin, Bulent, Dagalp, Kemal
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Celiac Disease - blood
Celiac Disease - complications
Enzyme-Linked Immunosorbent Assay
Esophagitis, Peptic - blood
Esophagitis, Peptic - complications
Female
Gliadin - immunology
Humans
Immunoglobulin A - blood
Immunoglobulin A - immunology
Immunoglobulin G - blood
Immunoglobulin G - immunology
Male
Middle Aged
Prospective Studies
Rapid Communication
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Summary:To investigate the prevalence of celiac disease serologic markers (antigliadin IgA, IgG, and anti-endomysial IgA) in patients with reflux esophagitis and to detect the relationship between reflux esophagitis and celiac disease (CD). This study was performed prospectively between January 2003 and January 2004. Sixty-eight adult reflux esophagitis patients and 40 people as control group for symptoms related with gastrointestinal system were enrolled in this study. The diagnostic work-up included an accurate medical history with gastrointestinal symptoms, routine laboratory measurements, the detection of antibodies against gliadin (IgA and IgG) and endomysium (IgA), and an upper endoscopy with postbulbar biopsy. IgA-AGA and IgG-AGA were positive at 8.8% and 10.3% in patients with reflux esophagitis. In control group, it was found that 10% people had positive IgA-AGA, and 7.5% people had positive IgG-AGA. There was no significant relationship between patients and control group regarding positive IgA-AGA and IgG-AGA. The patients and persons in control group had no positive IgA-EMA. On postbulbar biopsies, no finding was detected concerning celiac disease. There were no symptoms and signs for gluten enteropathy in patients and control group. This review supports that an association does not exist between celiac disease and reflux esophagitis. We think these diseases exist independently from each other.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v12.i41.6707