Accuracy of dual-energy computed tomography for the measurement of iodine concentration using cardiac CT protocols: validation in a phantom model

Purpose To assess the accuracy of dual-energy CT (DECT) for the quantification of iodine concentrations in a thoracic phantom across various cardiac DECT protocols and simulated patient sizes. Materials and methods Experiments were performed on first- and second-generation dual-source CT (DSCT) syst...

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Bibliographic Details
Published in:European radiology 2014-02, Vol.24 (2), p.512-518
Main Authors: Koonce, James D., Vliegenthart, Rozemarijn, Schoepf, U. Joseph, Schmidt, Bernhard, Wahlquist, Amy E., Nietert, Paul J., Bastarrika, Gorka, Flohr, Thomas G., Meinel, Felix G.
Format: Article
Language:English
Subjects:
Accuracy
Algorithms
Anthropomorphism
Blood
Cardiac
Cardiovascular disease
Diagnostic Radiology
Energy
Heart - diagnostic imaging
Humans
Imaging
Internal Medicine
Interventional Radiology
Iodine
Iodine - pharmacokinetics
Medicine
Medicine & Public Health
Myocardium - metabolism
Neuroradiology
Phantoms, Imaging
Radiography, Dual-Energy Scanned Projection - methods
Radiology
Reproducibility of Results
Software
Tomography
Ultrasound
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Summary:Purpose To assess the accuracy of dual-energy CT (DECT) for the quantification of iodine concentrations in a thoracic phantom across various cardiac DECT protocols and simulated patient sizes. Materials and methods Experiments were performed on first- and second-generation dual-source CT (DSCT) systems in DECT mode using various cardiac DECT protocols. An anthropomorphic thoracic phantom was equipped with tubular inserts containing known iodine concentrations (0–20 mg/mL) in the cardiac chamber and up to two fat-equivalent rings to simulate different patient sizes. DECT-derived iodine concentrations were measured using dedicated software and compared to true concentrations. General linear regression models were used to identify predictors of measurement accuracy Results Correlation between measured and true iodine concentrations ( n  = 72) across CT systems and protocols was excellent ( R  = 0.994–0.997, P  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-013-3040-6