Morphine and codeine concentrations in human urine following controlled poppy seeds administration of known opiate content

Highlights • Controlled administration of uncooked poppy seeds with known opiate content. • Each urine void collected for 32 h. • 26.6% specimens with morphine >2000 μg/L. • Median (range) peak morphine 5239 μg/L (2413–7522). • Last morphine >2000 μg/L 2.6–18 h after last dose....

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Bibliographic Details
Published in:Forensic science international 2014-08, Vol.241, p.87-90
Main Authors: Smith, Michael L, Nichols, Daniel C, Underwood, Paula, Fuller, Zachary, Moser, Matthew A, LoDico, Charles, Gorelick, David A, Newmeyer, Matthew N, Concheiro, Marta, Huestis, Marilyn A
Format: Article
Language:English
Subjects:
Analgesics, Opioid - urine
Assaying
Codeine
Codeine - urine
Controlled dose
Drug dosages
Drug testing
Female
Forensic sciences
Gas Chromatography-Mass Spectrometry
Heroin
Humans
Immunoassay
Ingestion
Male
Methods
Morphine
Morphine - urine
Narcotics
Papaver
Pathology
Poppies
Poppy seeds
Quality control
Seeds
Studies
Testing laboratories
Urine
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Summary:Highlights • Controlled administration of uncooked poppy seeds with known opiate content. • Each urine void collected for 32 h. • 26.6% specimens with morphine >2000 μg/L. • Median (range) peak morphine 5239 μg/L (2413–7522). • Last morphine >2000 μg/L 2.6–18 h after last dose.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2014.04.042