IgA dominant postinfectious glomerulonephritis: Report of two cases

Immunoglobulin A (IgA) dominant postinfectious glomerulonephritis (IgA PIGN) is a distinct clinical entity increasingly recognized in adult. It usually presents with reduced glomerular filtration rate, heavy proteinuria, and has unfavorable prognosis. Immunofluorescence study of renal biopsy specime...

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Bibliographic Details
Published in:Indian journal of nephrology 2014-05, Vol.24 (3), p.181-184
Main Authors: Rajakumar, V, Mohamed, S. A. K, Kurien, A, Fernando, M
Format: Article
Language:English
Subjects:
Case Report
Case studies
Genetic aspects
Glomerulonephritis
Immunoglobulin A
Physiological aspects
Prognosis
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Summary:Immunoglobulin A (IgA) dominant postinfectious glomerulonephritis (IgA PIGN) is a distinct clinical entity increasingly recognized in adult. It usually presents with reduced glomerular filtration rate, heavy proteinuria, and has unfavorable prognosis. Immunofluorescence study of renal biopsy specimens have IgA as dominant or codominant antibody. We encountered two cases of IgA dominant PIGN recently presenting as rapidly progr essive glomerulonephritis and managed conservatively. Both the patients are on follow-up and do not have complete recovery of renal function till date. Long-term follow-up is needed to assess the progression of the disease in these patients.
ISSN:0971-4065
1998-3662
DOI:10.4103/0971-4065.132020