Differences in intrinsic functional organization between dorsolateral prefrontal and posterior parietal cortex

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2014-09, Vol.24 (9), p.2334-2349
• Main Authors: Katsuki, Fumi, Qi, Xue-Lian, Meyer, Travis, Kostelic, Phillip M, Salinas, Emilio, Constantinidis, Christos
• Format: Article
• Language: English
• Subjects: Action Potentials; Animals; Computer Simulation; Macaca mulatta; Male; Memory, Short-Term - physiology; Microelectrodes; Neural Pathways - physiology; Neurons - physiology; Neuropsychological Tests; Parietal Lobe - physiology; Prefrontal Cortex - physiology
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bht087

The dorsolateral prefrontal and posterior parietal cortex are 2 components of the cortical network controlling attention, working memory, and executive function. Little is known about how the anatomical organization of the 2 areas accounts for their functional specialization. In order to address this question, we examined the strength of intrinsic functional connectivity between neurons sampled in each area by means of cross-correlation analyses of simultaneous recordings from monkeys trained to perform working memory tasks. In both areas, effective connectivity declined as a function of distance between neurons. However, the strength of effective connectivity was higher overall and more localized over short distances in the posterior parietal than the prefrontal cortex. The difference in connectivity strength between the 2 areas could not be explained by differences in firing rate or selectivity for the stimuli and task events, it was present when the fixation period alone was analyzed, and according to simulation results, was consistent with a systematic difference either in the strength or in the relative numbers of shared inputs between neurons. Our results indicate that the 2 areas are characterized by unique intrinsic functional organization, consistent with known differences in their response patterns during working memory.