Helicobacter pylori infection and drugs malabsorption

Drug absorption represents an important factor affecting the efficacy of oral drug treatment.Gastric secretion and motility seem to be critical for drug absorption.A causal relationship between impaired absorption of orally administered drugs and Helicobacter pylori(H.pylori)infection has been propo...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-08, Vol.20 (30), p.10331-10337
Main Authors: Lahner, Edith, Virili, Camilla, Santaguida, Maria Giulia, Annibale, Bruno, Centanni, Marco
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - pharmacokinetics
Antiparkinson Agents - administration & dosage
Antiparkinson Agents - pharmacokinetics
Biological Availability
Drug
Gastric Absorption
gastritis
Helicobacter
Helicobacter Infections - metabolism
Helicobacter Infections - microbiology
Helicobacter pylori - pathogenicity
Host-Pathogen Interactions
Humans
malabsorption
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - metabolism
pylori
Risk Factors
Stomach - metabolism
Stomach - microbiology
Thyroxine - administration & dosage
Thyroxine - pharmacokinetics
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Summary:Drug absorption represents an important factor affecting the efficacy of oral drug treatment.Gastric secretion and motility seem to be critical for drug absorption.A causal relationship between impaired absorption of orally administered drugs and Helicobacter pylori(H.pylori)infection has been proposed.Associations have been reported between poor bioavailability of l-thyroxine and l-dopa and H.pylori infection.According to the Maastricht Florence Consensus Report on the management of H.pylori infection,H.pylori treatment improves the bioavailability of both these drugs,whereas the direct clinical benefits to patients still await to be established.Less strong seems the association between H.pylori infection and other drugs malabsorption,such as delavirdine and ketoconazole.The exact mechanisms forming the basis of the relationship between H.pylori infection and impaired drugs absorption and/or bioavailability are not fully elucidated.H.pylori infection may trigger a chronic inflammation of the gastric mucosa,and impaired gastric acid secretion often follows.The reduction of acid secretion closely relates with the wideness and the severity of the damage and may affect drug absorption.This minireview focuses on the evidence of H.pylori infection associated with impaired drug absorption.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i30.10331