Pressure–Voltage Trap for DNA near a Solid-State Nanopore

We report the formation of a tunable single DNA molecule trap near a solid-state nanopore in an electrolyte solution under conditions where an electric force and a pressure-induced viscous flow force on the molecule are nearly balanced. Trapped molecules can enter the pore multiple times before esca...

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Bibliographic Details
Published in:ACS nano 2014-07, Vol.8 (7), p.7384-7391
Main Authors: Hoogerheide, David P, Lu, Bo, Golovchenko, Jene A
Format: Article
Language:English
Subjects:
DNA
Electricity
Kinetics
Movement
Nanopores
Pressure
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Summary:We report the formation of a tunable single DNA molecule trap near a solid-state nanopore in an electrolyte solution under conditions where an electric force and a pressure-induced viscous flow force on the molecule are nearly balanced. Trapped molecules can enter the pore multiple times before escaping the trap by passing through the pore or by diffusing away. Statistical analysis of many individually trapped molecules yields a detailed picture of the fluctuation phenomena involved, which are successfully modeled by a one-dimensional first passage approach.
ISSN:1936-0851
1936-086X
DOI:10.1021/nn5025829