Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer

Lung cancer is a disease with high morbidity and mortality rates. As a result, it is often associated with a significant amount of suffering and a general decrease in the quality of life. Herbal medicines are recognized as an attractive approach to lung cancer therapy with little side effects and ar...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-15
Main Authors: Diniz, Margareth de Fátima Formiga Melo, de Athayde-Filho, Petrônio Filgueiras, Barbosa Filho, José Maria, Bastos, Katherine Xavier, Monteiro, Luara de Sousa, Sobral, Marianna Vieira
Format: Article
Language:English
Subjects:
Antitumor activity
Apoptosis
Bioactive compounds
Biological activity
Cancer
Cancer therapies
Care and treatment
Catharanthus roseus
Chemotherapy
Data banks
Ganoderma lucidum
Growth factors
Health aspects
Herbal medicine
Kinases
Lung cancer
Lung carcinoma
Lung diseases
Medical prognosis
Medicinal plants
Metastasis
Morbidity
Mortality
Natural products
Oncology, Experimental
Plants (botany)
Quality of life
Review
Side effects
Smoking
Toxicity
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Summary:Lung cancer is a disease with high morbidity and mortality rates. As a result, it is often associated with a significant amount of suffering and a general decrease in the quality of life. Herbal medicines are recognized as an attractive approach to lung cancer therapy with little side effects and are a major source of new drugs. The aim of this work was to review the medicinal plants and other living organisms with antitumor potential against lung cancer. The assays were conducted with animals and humans, and Lewis lung carcinoma was the most used experimental model. China, Japan, South Korea, and Ethiopia were the countries that most published studies of species with antitumor activity. Of the 38 plants evaluated, 27 demonstrated antitumor activity. In addition, six other living organisms were cited for antitumor activity against lung cancer. Mechanisms of action, combination with chemotherapeutic drugs, and new technologies to increase activity and reduce the toxicity of the treatment are discussed. This review was based on the NAPRALERT databank, Web of Science, and Chemical Abstracts. This work shows that natural products from plants continue to be a rich source of herbal medicines or biologically active compounds against cancer.
ISSN:1741-427X
1741-4288
DOI:10.1155/2014/604152