Signal transductions and nonalcoholic fatty liver: a mini-review

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease, and the incidence increases year by year. The pathogenesis of NAFLD is correlated with insulin resistant (IR), and oxidative stress which induces varied inflammatory cytokines (TNF-α, IL-1, IL-6, etc). Different signal transductions...

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Bibliographic Details
Published in:International journal of clinical and experimental medicine 2014-01, Vol.7 (7), p.1624-1631
Main Authors: Zeng, Lu, Tang, Wai J, Yin, Jin J, Zhou, Bei J
Format: Article
Language:English
Subjects:
Review
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Summary:Nonalcoholic fatty liver disease (NAFLD) is a common liver disease, and the incidence increases year by year. The pathogenesis of NAFLD is correlated with insulin resistant (IR), and oxidative stress which induces varied inflammatory cytokines (TNF-α, IL-1, IL-6, etc). Different signal transductions such as MAPK, NF-κB, AMPK, JAK2/STAT3, PPAR, PI3K/Akt, TLR were activated by the pathogenic factors to regulate correlative reactions. Thus, in-depth study of the signal transductions will probably provide new suitable solutions for the prevention and therapy of NAFLD.
ISSN:1940-5901
1940-5901