The role of plasma gelsolin in cardiopulmonary bypass induced acute lung injury in infants and young children: a pilot study

Acute lung injury (ALI) induced by cardiopulmonary bypass (CPB, CPB-ALI) is a common and serious complication after cardiac surgery. And infants and young children are more prone to CPB-ALI. The purpose of this study was to investigate the perioperative changes of plasma gelsolin (pGSN) in patients...

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Bibliographic Details
Published in:BMC anesthesiology 2014-08, Vol.14 (1), p.67-67, Article 67
Main Authors: Shi, ShanShan, Chen, Chi, Zhao, DongYan, Liu, XiWang, Cheng, BaoLi, Wu, ShuiJing, Lin, Ru, Tan, LinHua, Fang, XiangMing, Shu, Qiang
Format: Article
Language:English
Subjects:
Acute Lung Injury - blood
Acute Lung Injury - etiology
Analysis
Blood Proteins - analysis
Cardiopulmonary Bypass - adverse effects
Child, Preschool
Colleges & universities
Female
Gelsolin - blood
Hospitals
Humans
Infant
Infant, Newborn
Male
Measurement
Medical research
Medicine, Experimental
Pilot Projects
Plasma
Predictive Value of Tests
Respiratory distress syndrome
Risk Factors
Systemic Inflammatory Response Syndrome - blood
Treatment Outcome
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Summary:Acute lung injury (ALI) induced by cardiopulmonary bypass (CPB, CPB-ALI) is a common and serious complication after cardiac surgery. And infants and young children are more prone to CPB-ALI. The purpose of this study was to investigate the perioperative changes of plasma gelsolin (pGSN) in patients below 3 years of age with cardiac surgeries and CPB, and determine whether pGSN are associated with the occurrence and severity of CPB-ALI. Seventy-seven consecutive patients ≤3 years of age with congenital heart diseases (CHD) performed on open heart surgery with CPB were finally enrolled, and assigned to ALI and non-ALI groups according to the American-European Consensus Criteria. Plasma concentrations of gelsolin and total protein were measured at following 8 time points: before CPB (a), after CPB (b), 2 hours after CPB (c), 6 hours after CPB (d), 12 hours after CPB (e), 24 hours after CPB (f), 48 hours after CPB (g) and 72 hours after CPB (h). Twenty-seven (35.1%) patients developed CPB-ALI in the study, including eleven (14.3%) patients with ARDS. The earliest significant drop of pGSN and normalized pGSN (pGSNN) of ALI group both occurred at 6 hours after CPB (p = 0.04 and p 
ISSN:1471-2253
1471-2253
DOI:10.1186/1471-2253-14-67