Mobile elements and viral integrations prompt considerations for bacterial DNA integration as a novel carcinogen

Highlights • Mobile elements can cause cancer by inserting into cancer-related genes. • Viruses contribute to carcinogenesis by mutating and deregulating human genes. • Microbes induce chronic inflammation as well as toxins that are linked to cancer. • Viral and mobile element integration allude to...

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Bibliographic Details
Published in:Cancer letters 2014-10, Vol.352 (2), p.137-144
Main Authors: Robinson, Kelly M, Dunning Hotopp, Julie C
Format: Article
Language:English
Subjects:
Animals
Bacteria
Bacterial Infections - genetics
Bacterial Infections - microbiology
Cell Transformation, Viral
Colorectal cancer
DNA, Bacterial - genetics
Epstein-Barr virus
Gene Expression Regulation, Neoplastic
Genes
Genetic Predisposition to Disease
Genomics
Hematology, Oncology and Palliative Medicine
Hepatitis B virus
Humans
Interspersed Repetitive Sequences
Lateral gene transfer
Mobile elements
Mutagenesis, Insertional
Mutation
Neoplasms - genetics
Neoplasms - microbiology
Neoplasms - pathology
Neoplasms - virology
Parasites
Phenotype
Polyomavirus
Risk Factors
Tumor Virus Infections - genetics
Tumor Virus Infections - virology
Virus Integration
Viruses
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Summary:Highlights • Mobile elements can cause cancer by inserting into cancer-related genes. • Viruses contribute to carcinogenesis by mutating and deregulating human genes. • Microbes induce chronic inflammation as well as toxins that are linked to cancer. • Viral and mobile element integration allude to microbial integration in the cancer genome. • New technologies may facilitate detecting microbial integrations in the human genome.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.05.021