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Antimutagenicity of Methanolic Extracts from Anemopsis californica in Relation to Their Antioxidant Activity

Anemopsis californica has been used empirically to treat infectious diseases. However, there are no antimutagenic evaluation reports on this plant. The present study evaluated the antioxidant activity in relation to the mutagenic and antimutagenic activity properties of leaf (LME) and stem (SME) met...

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Published in:Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-8
Main Authors: Gutiérrez-Lomelí, Melesio, Gonzalez-Ávila, Marisela, Blasco-Cabal, José Luis, Bautista-Bautista, Nereyda, Del-Toro-Sánchez, Carmen Lizette, Arriaga-Alba, Myriam
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Language:English
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Summary:Anemopsis californica has been used empirically to treat infectious diseases. However, there are no antimutagenic evaluation reports on this plant. The present study evaluated the antioxidant activity in relation to the mutagenic and antimutagenic activity properties of leaf (LME) and stem (SME) methanolic extracts of A. californica collected in the central Mexican state of Querétaro. Antioxidant properties and total phenols of extracts were evaluated using DPPH (1,1-diphenyl-2-picrylhydrazyl) and Folin-Ciocalteu methods, respectively. Mutagenicity was evaluated using the Ames test employing Salmonella enterica serovar Typhimurium strains (TA98, TA100, and TA102), with and without an aroclor 1254 (S9 mixture). Antimutagenesis was performed against mutations induced on the Ames test with MNNG, 2AA, or 4NQO. SME presented the highest antioxidant capacity and total phenolic content. None of the extracts exhibited mutagenicity in the Ames test. The extracts produced a significant reduction in 2AA-induced mutations in S. typhimurium TA98. In both extracts, mutagenesis induced by 4NQO or methyl-N′-nitro-N-nitrosoguanidine (MNNG) was reduced only if the exposure of strains was
ISSN:1741-427X
1741-4288
DOI:10.1155/2014/273878