Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults

Highlights • The safety profile of live mycobacterial vaccines in TB infected adults is unknown. • BCG revaccination of adults with latent TB infection was safe and well tolerated. • Reactogenicity of BCG revaccination was unaffected by isoniazid pretreatment. • Trials of live mycobacterial vaccines...

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Published in:Vaccine 2014-06, Vol.32 (31), p.3982-3988
Main Authors: Hatherill, Mark, Geldenhuys, Hendrik, Pienaar, Bernadette, Suliman, Sara, Chheng, Phalkun, Debanne, Sara M, Hoft, Daniel F, Boom, W. Henry, Hanekom, Willem A, Johnson, John L
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Applied microbiology
BCG
BCG Vaccine - adverse effects
BCG Vaccine - therapeutic use
Biological and medical sciences
Clinical trials
Disease
Female
Fundamental and applied biological sciences. Psychology
Human immunodeficiency virus
Humans
Immunization, Secondary - adverse effects
Infections
Isoniazid
Isoniazid - administration & dosage
Latent Tuberculosis - diagnosis
Latent Tuberculosis - prevention & control
LTBI
Male
Microbiology
Mycobacterium
Public health
Revaccination
Safety
Skin
South Africa
Tuberculin Test
Tuberculosis
Ulcers
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Young Adult
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container_end_page 3988
container_issue 31
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container_title Vaccine
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creator Hatherill, Mark
Geldenhuys, Hendrik
Pienaar, Bernadette
Suliman, Sara
Chheng, Phalkun
Debanne, Sara M
Hoft, Daniel F
Boom, W. Henry
Hanekom, Willem A
Johnson, John L
description Highlights • The safety profile of live mycobacterial vaccines in TB infected adults is unknown. • BCG revaccination of adults with latent TB infection was safe and well tolerated. • Reactogenicity of BCG revaccination was unaffected by isoniazid pretreatment. • Trials of live mycobacterial vaccines may be considered in TB infected adults.
doi_str_mv 10.1016/j.vaccine.2014.04.084
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subjects Adult
Allergy and Immunology
Applied microbiology
BCG
BCG Vaccine - adverse effects
BCG Vaccine - therapeutic use
Biological and medical sciences
Clinical trials
Disease
Female
Fundamental and applied biological sciences. Psychology
Human immunodeficiency virus
Humans
Immunization, Secondary - adverse effects
Infections
Isoniazid
Isoniazid - administration & dosage
Latent Tuberculosis - diagnosis
Latent Tuberculosis - prevention & control
LTBI
Male
Microbiology
Mycobacterium
Public health
Revaccination
Safety
Skin
South Africa
Tuberculin Test
Tuberculosis
Ulcers
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Young Adult
title Safety and reactogenicity of BCG revaccination with isoniazid pretreatment in TST positive adults
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