Comparative efficacies of cloxacillin-daptomycin and the standard cloxacillin-rifampin therapies against an experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus

We compared the efficacies of daptomycin (doses equivalent to 8 to 10 mg/kg of body weight/day in humans) and cloxacillin alone with those of cloxacillin-rifampin and cloxacillin-daptomycin combinations, using a tissue cage methicillin-susceptible Staphylococcus aureus (MSSA) infection model. Monoth...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2014-09, Vol.58 (9), p.5576-5580
Main Authors: El Haj, Cristina, Murillo, Oscar, Ribera, Alba, Vivas, Mireia, Garcia-Somoza, Dolors, Tubau, Fe, Cabo, Javier, Ariza, Javier
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Cloxacillin
Cloxacillin - pharmacokinetics
Cloxacillin - therapeutic use
Daptomycin
Daptomycin - pharmacokinetics
Daptomycin - therapeutic use
Drug Combinations
Experimental Therapeutics
Microbial Sensitivity Tests
Rats
Rats, Wistar
Rifampin
Rifampin - pharmacokinetics
Rifampin - therapeutic use
Staphylococcal Infections
Staphylococcal Infections - drug therapy
Staphylococcus aureus
Staphylococcus aureus - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We compared the efficacies of daptomycin (doses equivalent to 8 to 10 mg/kg of body weight/day in humans) and cloxacillin alone with those of cloxacillin-rifampin and cloxacillin-daptomycin combinations, using a tissue cage methicillin-susceptible Staphylococcus aureus (MSSA) infection model. Monotherapies were less effective than combinations (P
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02681-14