Trends in sex hormone concentrations in US males: 1988-1991 to 1999-2004

Summary Previous studies suggest that male testosterone concentrations have declined over time. To explore this in a large US population, we examined testosterone and free testosterone concentrations in National Health and Nutrition Examination Surveys (NHANES) from 1988–1991 and 1999–2004. We also...

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Bibliographic Details
Published in:International journal of andrology 2012-06, Vol.35 (3), p.456-466
Main Authors: Nyante, S. J., Graubard, B. I., Li, Y., McQuillan, G. M., Platz, E. A., Rohrmann, S., Bradwin, G., McGlynn, K. A.
Format: Article
Language:English
Subjects:
Adult
African Continental Ancestry Group
Aged
Androstane-3,17-diol - analogs & derivatives
Androstane-3,17-diol - blood
androstanediol glucuronide
epidemiology
estradiol
Estradiol - blood
European Continental Ancestry Group
Gonadal Steroid Hormones - blood
Humans
Male
Mexican Americans
Middle Aged
National Health and Nutrition Examination Survey
Nutrition Surveys
sex hormone-binding globulin
Sex Hormone-Binding Globulin - analysis
testosterone
Testosterone - blood
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Summary:Summary Previous studies suggest that male testosterone concentrations have declined over time. To explore this in a large US population, we examined testosterone and free testosterone concentrations in National Health and Nutrition Examination Surveys (NHANES) from 1988–1991 and 1999–2004. We also examined sex hormone‐binding globulin (SHBG), estradiol, and androstanediol glucuronide (3α‐diol‐G) over the same period. Non‐Hispanic white, non‐Hispanic black, and Mexican‐American men from 1988–1991 and 1999–2004 NHANES surveys who were ≥20 years old and had serum from morning blood draws were included in this analysis (1988–1991: N = 1,413; 1999–2004: N = 902). Testosterone, estradiol and SHBG were measured by competitive electrochemiluminescence immunoassays and 3α‐diol‐G was measured by enzyme immunoassay. Free testosterone was calculated using testosterone and SHBG values. Adjusted mean hormone concentrations were estimated using linear regression, accounting for NHANES sampling weights and design, age, race/ethnicity, body mass index, waist circumference, alcohol use and smoking. Differences in adjusted mean concentrations (Δ) and two‐sided p‐values were calculated; p 
ISSN:0105-6263
1365-2605
DOI:10.1111/j.1365-2605.2011.01230.x