Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury

The aim of this study was to examine whether dexmedetomidine improves acute liver injury in a rat model. Twenty-eight male Wistar albino rats weighing 300–350 g were allocated randomly to four groups. In group 1, normal saline (NS) was injected into the lungs and rats were allowed to breathe spontan...

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Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-11
Main Authors: Şen, Velat, Güzel, Abdulmenap, Selimoğlu Şen, Hadice, Ece, Aydın, Uluca, Ünal, Söker, Sevda, Doğan, Erdal, Kaplan, İbrahim, Deveci, Engin
Format: Article
Language:English
Subjects:
Acute respiratory distress syndrome
Albinism
Analgesics
Animal models in research
Animals
Antioxidants - metabolism
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - metabolism
Chemical and Drug Induced Liver Injury - pathology
Cytokines
Dexmedetomidine
Dexmedetomidine - administration & dosage
Drug therapy
Experiments
Gene Expression Regulation - drug effects
Health aspects
Histology
Humans
Hydrochloric Acid - toxicity
Hypoxia
Ischemia
Laboratory animals
Liver
Liver - drug effects
Malondialdehyde - metabolism
Medical schools
Mortality
Oxidative stress
Oxidative Stress - drug effects
Rats
Rodents
Studies
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - biosynthesis
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creator Şen, Velat
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Söker, Sevda
Doğan, Erdal
Kaplan, İbrahim
Deveci, Engin
description The aim of this study was to examine whether dexmedetomidine improves acute liver injury in a rat model. Twenty-eight male Wistar albino rats weighing 300–350 g were allocated randomly to four groups. In group 1, normal saline (NS) was injected into the lungs and rats were allowed to breathe spontaneously. In group 2, rats received standard ventilation (SV) in addition to NS. In group 3, hydrochloric acid was injected into the lungs and rats received SV. In group 4, rats received SV and 100 µg/kg intraperitoneal dexmedetomidine before intratracheal HCl instillation. Blood samples and liver tissue specimens were examined by biochemical, histopathological, and immunohistochemical methods. Acute lung injury (ALI) was found to be associated with increased malondialdehyde (MDA), total oxidant activity (TOA), oxidative stress index (OSI), and decreased total antioxidant capacity (TAC). Significantly decreased MDA, TOA, and OSI levels and significantly increased TAC levels were found with dexmedetomidine injection in group 4 (P
doi_str_mv 10.1155/2014/621827
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Twenty-eight male Wistar albino rats weighing 300–350 g were allocated randomly to four groups. In group 1, normal saline (NS) was injected into the lungs and rats were allowed to breathe spontaneously. In group 2, rats received standard ventilation (SV) in addition to NS. In group 3, hydrochloric acid was injected into the lungs and rats received SV. In group 4, rats received SV and 100 µg/kg intraperitoneal dexmedetomidine before intratracheal HCl instillation. Blood samples and liver tissue specimens were examined by biochemical, histopathological, and immunohistochemical methods. Acute lung injury (ALI) was found to be associated with increased malondialdehyde (MDA), total oxidant activity (TOA), oxidative stress index (OSI), and decreased total antioxidant capacity (TAC). Significantly decreased MDA, TOA, and OSI levels and significantly increased TAC levels were found with dexmedetomidine injection in group 4 (P&lt;0.05). The highest histologic injury scores were detected in group 3. Enhanced hepatic vascular endothelial growth factor (VEGF) expression and reduced CD68 expression were found in dexmedetomidine group compared with the group 3. In conclusion, the presented data provide the first evidence that dexmedetomidine has a protective effect on experimental liver injury induced by ALI.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/621827</identifier><identifier>PMID: 25165710</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Acute respiratory distress syndrome ; Albinism ; Analgesics ; Animal models in research ; Animals ; Antioxidants - metabolism ; Chemical and Drug Induced Liver Injury - drug therapy ; Chemical and Drug Induced Liver Injury - metabolism ; Chemical and Drug Induced Liver Injury - pathology ; Cytokines ; Dexmedetomidine ; Dexmedetomidine - administration &amp; dosage ; Drug therapy ; Experiments ; Gene Expression Regulation - drug effects ; Health aspects ; Histology ; Humans ; Hydrochloric Acid - toxicity ; Hypoxia ; Ischemia ; Laboratory animals ; Liver ; Liver - drug effects ; Malondialdehyde - metabolism ; Medical schools ; Mortality ; Oxidative stress ; Oxidative Stress - drug effects ; Rats ; Rodents ; Studies ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - biosynthesis</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-11</ispartof><rights>Copyright © 2014 Velat Şen et al.</rights><rights>COPYRIGHT 2014 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2014 Velat Sen et al. Velat Sen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Velat Şen et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-f635243e4d6927d3bdc980066578161390fdef39d4e3d6752b846e8cb1745ee23</citedby><cites>FETCH-LOGICAL-c593t-f635243e4d6927d3bdc980066578161390fdef39d4e3d6752b846e8cb1745ee23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1553698601/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1553698601?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25752,27923,27924,37011,37012,44589,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25165710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Jung, Boris</contributor><creatorcontrib>Şen, Velat</creatorcontrib><creatorcontrib>Güzel, Abdulmenap</creatorcontrib><creatorcontrib>Selimoğlu Şen, Hadice</creatorcontrib><creatorcontrib>Ece, Aydın</creatorcontrib><creatorcontrib>Uluca, Ünal</creatorcontrib><creatorcontrib>Söker, Sevda</creatorcontrib><creatorcontrib>Doğan, Erdal</creatorcontrib><creatorcontrib>Kaplan, İbrahim</creatorcontrib><creatorcontrib>Deveci, Engin</creatorcontrib><title>Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>The aim of this study was to examine whether dexmedetomidine improves acute liver injury in a rat model. 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subjects Acute respiratory distress syndrome
Albinism
Analgesics
Animal models in research
Animals
Antioxidants - metabolism
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - metabolism
Chemical and Drug Induced Liver Injury - pathology
Cytokines
Dexmedetomidine
Dexmedetomidine - administration & dosage
Drug therapy
Experiments
Gene Expression Regulation - drug effects
Health aspects
Histology
Humans
Hydrochloric Acid - toxicity
Hypoxia
Ischemia
Laboratory animals
Liver
Liver - drug effects
Malondialdehyde - metabolism
Medical schools
Mortality
Oxidative stress
Oxidative Stress - drug effects
Rats
Rodents
Studies
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - biosynthesis
title Preventive Effects of Dexmedetomidine on the Liver in a Rat Model of Acid-Induced Acute Lung Injury
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