Metabolic Acidosis and Strong Ion Gap in Critically Ill Patients with Acute Kidney Injury

Purpose. To determine the influence of physicochemical parameters on survival in metabolic acidosis (MA) and acute kidney injury (AKI) patients. Materials and Methods. Seventy-eight MA patients were collected and assigned to AKI or non-AKI group. We analyzed the physiochemical parameters on survival...

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Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-8
Main Authors: Zheng, Cai-Mei, Liu, Wen-Chih, Zheng, Jing-Quan, Liao, Min-Tser, Ma, Wen-Ya, Hung, Kuo-Chin, Lu, Chien-Lin, Wu, Chia-Chao, Lu, Kuo-Cheng
Format: Article
Language:English
Subjects:
Acid-Base Equilibrium
Acidosis
Acidosis - metabolism
Acidosis - mortality
Acidosis - pathology
Acute Kidney Injury - metabolism
Acute Kidney Injury - mortality
Acute Kidney Injury - pathology
Acute renal failure
Aged
Biomedical research
Critical Illness - mortality
Critically ill
Development and progression
Female
Hospital Mortality
Humans
Intensive Care Units
Kidney Function Tests
Male
Middle Aged
Osmolar Concentration
Physiological aspects
Retrospective Studies
Serum Albumin
Survival Analysis
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Summary:Purpose. To determine the influence of physicochemical parameters on survival in metabolic acidosis (MA) and acute kidney injury (AKI) patients. Materials and Methods. Seventy-eight MA patients were collected and assigned to AKI or non-AKI group. We analyzed the physiochemical parameters on survival at 24 h, 72 h, 1 week, 1 month, and 3 months after AKI. Results. Mortality rate was higher in the AKI group. AKI group had higher anion gap (AG), strong ion gap (SIG), and apparent strong ion difference (SIDa) values than non-AKI group. SIG value was higher in the AKI survivors than nonsurvivors and this value was correlated serum creatinine, phosphate, albumin, and chloride levels. SIG and serum albumin are negatively correlated with Acute Physiology and Chronic Health Evaluation IV scores. AG was associated with mortality at 1 and 3 months post-AKI, whereas SIG value was associated with mortality at 24 h, 72 h, 1 week, 1 month, and 3 months post-AKI. Conclusions. Whether high or low SIG values correlate with mortality in MA patients with AKI depends on its correlation with serum creatinine, chloride, albumin, and phosphate (P) levels. AG predicts short-term mortality and SIG value predicts both short- and long-term mortality among MA patients with AKI.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/819528