Nerve Regenerative Effects of GABA-B Ligands in a Model of Neuropathic Pain

Neuropathic pain arises as a direct consequence of a lesion or disease affecting the peripheral somatosensory system. It may be associated with allodynia and increased pain sensitivity. Few studies correlated neuropathic pain with nerve morphology and myelin proteins expression. Our aim was to test...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-13
Main Authors: Magnaghi, Valerio, Castelnovo, Luca Franco, Faroni, Alessandro, Cavalli, Erica, Caffino, Lucia, Colciago, Alessandra, Procacci, Patrizia, Pajardi, Giorgio
Format: Article
Language:English
Subjects:
Animals
Baclofen - administration & dosage
Biomedical research
Care and treatment
Diabetic neuropathy
GABA
gamma-Aminobutyric Acid - metabolism
Gene Expression
Humans
Hyperalgesia - drug therapy
Hyperalgesia - metabolism
Hyperalgesia - physiopathology
Hypotheses
Ligands
Medical research
Medicine, Experimental
Myelin Proteins - biosynthesis
Myelin Sheath - genetics
Myelin Sheath - metabolism
Nerve Regeneration
Nervous system
Neuralgia - drug therapy
Neuralgia - physiopathology
Pain
Pain management
Physiological aspects
Rats
Regeneration
Rodents
Sciatic Nerve - metabolism
Sciatic Nerve - physiopathology
Sciatic Neuropathy - drug therapy
Sciatic Neuropathy - physiopathology
Studies
Surgery
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Summary:Neuropathic pain arises as a direct consequence of a lesion or disease affecting the peripheral somatosensory system. It may be associated with allodynia and increased pain sensitivity. Few studies correlated neuropathic pain with nerve morphology and myelin proteins expression. Our aim was to test if neuropathic pain is related to nerve degeneration, speculating whether the modulation of peripheral GABA-B receptors may promote nerve regeneration and decrease neuropathic pain. We used the partial sciatic ligation- (PSL-) induced neuropathic model. The biochemical, morphological, and behavioural outcomes of sciatic nerve were analysed following GABA-B ligands treatments. Simultaneous 7-days coadministration of baclofen (10 mg/kg) and CGP56433 (3 mg/kg) alters tactile hypersensitivity. Concomitantly, specific changes of peripheral nerve morphology, nerve structure, and myelin proteins (P0 and PMP22) expression were observed. Nerve macrophage recruitment decreased and step coordination was improved. The PSL-induced changes in nociception correlate with altered nerve morphology and myelin protein expression. Peripheral synergic effects, via GABA-B receptor activation, promote nerve regeneration and likely ameliorate neuropathic pain.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/368678