Insights into the Structure and Dynamics of Measles Virus Nucleocapsids by 1H-detected Solid-state NMR

1H-detected solid-state nuclear magnetic resonance (NMR) experiments are recorded on both intact and trypsin-cleaved sedimented measles virus (MeV) nucleocapsids under ultra-fast magic-angle spinning. High-resolution 1H,15N-fingerprints allow probing the degree of molecular order and flexibility of...

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Published in:Biophysical journal 2014-08, Vol.107 (4), p.941-946
Main Authors: Barbet-Massin, Emeline, Felletti, Michele, Schneider, Robert, Jehle, Stefan, Communie, Guillaume, Martinez, Nicolas, Jensen, Malene Ringkjøbing, Ruigrok, Rob W.H., Emsley, Lyndon, Lesage, Anne, Blackledge, Martin, Pintacuda, Guido
Format: Article
Language:English
Subjects:
Escherichia coli
Measles virus - chemistry
Microscopy, Electron, Transmission
Models, Molecular
Nucleocapsid - chemistry
Proteins and Nucleic Acids
Proton Magnetic Resonance Spectroscopy
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cited_by cdi_FETCH-LOGICAL-c2968-a30a2e0a0e09d994cd637343cb6dfa8d2aa3fefe29f07781ddd07c9a097ede13
cites cdi_FETCH-LOGICAL-c2968-a30a2e0a0e09d994cd637343cb6dfa8d2aa3fefe29f07781ddd07c9a097ede13
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container_title Biophysical journal
container_volume 107
creator Barbet-Massin, Emeline
Felletti, Michele
Schneider, Robert
Jehle, Stefan
Communie, Guillaume
Martinez, Nicolas
Jensen, Malene Ringkjøbing
Ruigrok, Rob W.H.
Emsley, Lyndon
Lesage, Anne
Blackledge, Martin
Pintacuda, Guido
description 1H-detected solid-state nuclear magnetic resonance (NMR) experiments are recorded on both intact and trypsin-cleaved sedimented measles virus (MeV) nucleocapsids under ultra-fast magic-angle spinning. High-resolution 1H,15N-fingerprints allow probing the degree of molecular order and flexibility of individual capsid proteins, providing an exciting atomic-scale complement to electro microscopy (EM) studies of the same systems.
doi_str_mv 10.1016/j.bpj.2014.05.048
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subjects Escherichia coli
Measles virus - chemistry
Microscopy, Electron, Transmission
Models, Molecular
Nucleocapsid - chemistry
Proteins and Nucleic Acids
Proton Magnetic Resonance Spectroscopy
title Insights into the Structure and Dynamics of Measles Virus Nucleocapsids by 1H-detected Solid-state NMR
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